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GenomicsProtein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy
Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy
PRJNA854161 | ENA
UnknownSAR by kinetics for drug discovery in protein misfolding diseases.
Not available
S-EPMC6187117 | biostudies-literature
ProteomicsExpression dynamics in mammalian cells responding to protein misfolding stress
The relative importance of gene expression regulation at the mRNA versus the protein-level is a matter of ongoing debate. We present an in-depth analysis of a cervical cancer cell line responding to protein misfolding stress induced by dithiothreitol treatment, quantifying the dynamics of mRNA and p...
ORGANISM(S): Homo sapiens (Human) 
2016-03-14 | PXD002039 | Pride
Human Lc-msms Protein misfolding stress Hela 
GenomicsDELE1 mitochondrial integrated stress response to CHCHD10 G58R protein misfolding in striated muscle [RNA-seq]
DELE1 mitochondrial integrated stress response to CHCHD10 G58R protein misfolding in striated muscle [RNA-seq]
PRJNA1141402 | ENA
OtherProtein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy
Mitophagy is essential to maintain mitochondrial function and prevent diseases. It activates upon mitochondria depolarization, which causes PINK1 stabilization on the mitochondrial outer membrane. Strikingly, a number of conditions, including mitochondrial protein misfolding, can induce mitophagy wi...
ORGANISM(S): Homo sapiens 
2022-08-04 | GSE207212 | GEO
UnknownPrion protein misfolding.
Not available
S-EPMC3330701 | biostudies-literature
GenomicsRedox control of the cAMP/PKA pathway during protein misfolding stress
Redox control of the cAMP/PKA pathway during protein misfolding stress
PRJEB39415 | ENA
TranscriptomicsDELE1 mitochondrial integrated stress response to CHCHD10 G58R protein misfolding in striated muscle [RNA-seq]
Transcriptional mitochondrial stress response to CHCHD10 G58R protein misfolding in mouse heart, gastrocnemius, and tibalis anterior muscle the presence and absence of the DELE1 mitochondrial integrated stress responses
ORGANISM(S): Mus musculus 
2024-07-31 | GSE273310 | GEO
TranscriptomicsExpression dynamics in mammalian cells responding to protein misfolding stress
We have employed whole genome microarray expression profiling to track the transcriptome expression change under DTT induced protein misfolding stress. The relative importance of gene expression regulation at the mRNA versus the protein-level is a matter of ongoing debate. We present an in-depth ana...
ORGANISM(S): Homo sapiens 
2015-08-15 | GSE67901 | GEO
TranscriptomicsRedox control of the cAMP/PKA pathway during protein misfolding stress
Protein aggregation is the abnormal association of misfolded proteins into larger, often insoluble structures that can be toxic during ageing and in protein aggregation-associated diseases. This RNA-seq study in Saccharomyces cerevisiae investigated the role of Tsa1, which is a member of the highly ...
ORGANISM(S): Saccharomyces cerevisiae 
2021-04-19 | E-MTAB-9355 | biostudies-arrayexpress
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