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ProteomicsDeep single-cell proteomics quantifies low-abundant embryonic transcription factors and lineage markers during induced pluripotent stem cell differentiation
Single-cell proteomics (SCP) promises to revolutionize biomedicine by providing an unparalleled view of the proteome in individual cells. Here, we present a high-sensitivity SCP workflow identifying >5000 proteins in individual HeLa cells. It also facilitated direct detection of post-translational m...
ORGANISM(S): Homo sapiens (Human) 
2024-08-17 | PXD049211 | Pride
Single-cell proteomics Proteochip evo 96 Orbitrap astral 
ProteomicsDeep single-cell proteomics quantifies low-abundant embryonic transcription factors and lineage markers during induced pluripotent stem cell differentiation
Single-cell proteomics (SCP) promises to revolutionize biomedicine by providing an unparalleled view of the proteome in individual cells. Here, we present a high-sensitivity SCP workflow identifying >5000 proteins in individual HeLa cells. It also facilitated direct detection of post-translational m...
ORGANISM(S): Homo sapiens (Human) 
2024-08-17 | PXD049181 | Pride
Single-cell proteomics Proteochip evo 96 Orbitrap astral 
ProteomicsAn automated and fast sample preparation workflow for laser microdissection guided ultrasensitive proteomics
Spatial tissue proteomics integrating whole-slide imaging, laser microdissection and ultrasensitive mass spectrometry is a powerful approach to link cellular phenotypes to functional proteome states in (patho)physiology. To be applicable to large patient cohorts and low sample input amounts, includi...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-03-22 | PXD047762 | Pride
Spatial proteomics Mass spectrometry Tissue proteomics Sample preparation Robotics 
UnknownAutomated single-cell proteomics providing sufficient proteome depth to study complex biology beyond cell type classifications.
Not available
S-EPMC10849471 | biostudies-literature
UnknownAn Automated and Fast Sample Preparation Workflow for Laser Microdissection Guided Ultrasensitive Proteomics.
Not available
S-EPMC11067455 | biostudies-literature
ProteomicsDeep single-cell proteomics quantifies low-abundant embryonic transcription factors and lineage markers during induced pluripotent stem cell differentiation
Single-cell proteomics (SCP) promises to revolutionize biomedicine by providing an unparalleled view of the proteome in individual cells. Here, we present a high-sensitivity SCP workflow identifying >5000 proteins in individual HeLa cells. It also facilitated direct detection of post-translational m...
ORGANISM(S): Homo sapiens (Human) 
2024-08-17 | PXD054066 | Pride
Single-cell proteomics 
ProteomicsOvercoming preservation challenges to enable single-cell proteomics of fixed cell and tissue samples with retained proteome integrity
Recent advances in single-cell proteomics (SCP) now enable the unbiased quantification of the proteome to a depth of several thousand proteins across hundreds of cells. Yet the broader adoption beyond specialised groups remains limited due to the need for specific equipment and expertise. A major ch...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-05-23 | PXD061710 | Pride
Human Pancreas Mouse Lc-ms/ms Scp 
ProteomicsFormaldehyde fixation helps preserve the proteome state during single-cell proteomics sample processing and analysis
Mass spectrometry-based single-cell proteomics (SCP) is gaining momentum but remains limited to a few laboratories due to the high costs and specialized expertise required. The ability to send samples to specialized core facilities would benefit non-specialist labs and popularize SCP for biological ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD056327 | Pride
Single-cell proteomics Formaldehyde fixation Facs One-tip 
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