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ProteomicsStructure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs
Targeted membrane protein degradation using cell surface E3 ligases RNF43/ZNRF3 via proteolysis targeting chimeras (PROTACs) represents an effective strategy for treating membrane drug targets that cannot be fully inhibited using traditional inhibitors. Several ingenious chimeras have been developed...
ORGANISM(S): Homo Sapiens 
2025-03-04 | PXD061425 |
ProteomicsNovel proteolysis targeting chimera (PROTAC) selectively targeting Leucine Zipper-bearing Kinase (LZK) limits oncogenic potential of head and neck cancers.
Head and neck squamous cell carcinomas (HNSCC) are aggressive epithelial tumors with a low and unchanged 50% 5-year survival rate. MAP3K13 gene encoding Leucine Zipper-bearing Kinase (LZK) is often amplified in HNSCC patients and can be an oncogenic driver for tumorigenesis. In order to reduce catal...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD054481 | Pride
Leucine zipper-bearing kinase Lzk Head and neck cancer Targeted protein degradation Protac Map3k13 Proteolysis targeting chimera Hnscc 
GenomicsRUNX1 knockdown and BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mtRUNX1 AML cells
RUNX1 knockdown and BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mtRUNX1 AML cells
PRJNA488623 | ENA
UnknownSpecific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC).
Not available
S-EPMC12755880 | biostudies-literature
UnknownChemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC).
Not available
S-EPMC5555382 | biostudies-literature
ProteomicsIdentification of protein substrates of a novel proteolysis targeting chimera, PROTAC124 in tongue squamous cell carcinoma cell line CAL-33 overexpressing Leucine Zipper-bearing Kinase (LZK).
Head and neck squamous cell carcinomas (HNSCC) are aggressive epithelial tumors with a low and unchanged 50% 5-year survival rate. MAP3K13 gene encoding Leucine Zipper-bearing Kinase (LZK) is often amplified in HNSCC patients and can be an oncogenic driver for tumorigenesis. In order to reduce catal...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD057778 | Pride
Map3k13) Head and neck cancer Targeted protein degradation Protac (proteolysis targeting chimera) Hnscc Leucine zipper-bearing kinase (lzk 
UnknownProteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy.
Not available
S-EPMC7218526 | biostudies-literature
UnknownRational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC).
Not available
S-EPMC11874035 | biostudies-literature
UnknownHighly efficient and long-acting split-and-mix proteolysis targeting chimera based on self-assembled polylactic acid.
Not available
S-EPMC12658001 | biostudies-literature
UnknownTelomerase reverse transcriptase degradation via a rationally designed covalent proteolysis targeting chimera.
Not available
S-EPMC12671517 | biostudies-literature
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