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MetabolomicsThermal Profiling Maps Multilayered Organization of the Mitochondrial Proteome

Mitochondria execute essential metabolic, biosynthetic, and signaling functions, yet the regulatory principles governing their proteome remain incompletely understood. Here, we develop a thermal proteome profiling (TPP) workflow applied directly to purified mitochondria, enabling systematic analy...

2025-12-08 | MTBLS7386 | MetaboLights
MetabolomicsIntegrated proteome and lipidome analyses place OCIAD1 at mitochondria-peroxisome intersection balancing lipid metabolism

OCIAD1 (Ovarian Cancer Immunoreactive Antigen Domain Containing 1) is a membrane protein largely localized to mitochondria, however, its function in health or disease is not well understood. To comprehensively characterize the molecular changes upon lack of OCIAD1, we used mass spectrometry to st...

2025-04-25 | MTBLS12329 | MetaboLights
MetabolomicsMetabolome and proteome changes in skeletal muscle and blood of pre-weaning calves fed leucine and threonine supplemented diets

In pre-weaning calves, both leucine and threonine play important roles in growth and muscle metabolism. In this study, metabolomics, proteomics and clinical chemistry were used to assess the effects of leucine and threonine supplementation added to milk replacer on 14 newborn Holstein male calves...

2020-02-20 | MTBLS1045 | MetaboLights
UnknownIntrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits.
Not available
S-EPMC5066306 | biostudies-literature
ProteomicsAn Essential Factor for Apicoplast Fission and Inheritance in Malaria Parasites
Blood-stage Plasmodium falciparum parasites rely on a non-photosynthetic plastid, the apicoplast, for survival, making it an attractive target for antimalarial intervention. Like the mitochondrion, the apicoplast cannot be generated de novo and must be inherited by daughter parasites during cell div...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-10-27 | PXD062126 | Pride
Plasmodium falciparum Mitochondrial fission Pfanchor Apicoplast Gtpase Dynamin adaptor protein 
ProteomicsMultigenerational effect of heat stress on the Drosophila melanogaster sperm proteome
The notion that genes are the sole units of heredity and that a barrier exists between soma and germline has been a major hurdle in elucidating the heritability of traits that were observed to follow a non-Mendelian inheritance pattern. It was only after the conception of “epigenetics” by C. H. Wadd...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-05-10 | PXD037488 | Pride
White- mottled Multigenerational epigenetic inheritance Drosophila melanogaster Sperm proteome Heat stress 
ProteomicsTranscriptome sequencingand mass spectrometry reveal genes involved in the feather growth rate not conforming to Mendelian inheritance in chicken
To identify mechanisms related to feather growth rate in chickens that is not in consistent with Mendelian inheritance law, we integrate transcriptome and proteome to analyze thedifferentially expressed genes (DEGs) and proteins (DEPs) between the EC and LC versus the EH and LH.
ORGANISM(S): Gallus Gallus 
2023-11-14 | PXD046972 |
ProteomicsInheritance of old mitochondria controls early CD8+ T cell fate commitment and is regulated by autophagy - Pride 2
T cell immunity is impaired during ageing, particularly in memory responses needed for efficient vaccination. Autophagy and asymmetric cell division (ACD) are cell biological mechanisms key to memory formation, which undergo a decline upon ageing. However, despite the fundamental importance of these...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-21 | PXD053316 | Pride
Mitochondria Cd* t cells 
ProteomicsThe chromatin modifiers SET-25 and SET-32 are required for initiation but not long-term maintenance of transgenerational epigenetic inheritance
Some epigenetic modifications are inherited from one generation to the next, providing a potential mechanism for the inheritance of environmentally acquired traits. Transgenerational inheritance of RNA interference phenotypes in C. elegans provides an excellent model to study this phenomenon, and wh...
ORGANISM(S): Caenorhabditis elegans 
2018-10-30 | PXD008754 | Pride
C. elegans chromatin Rnai 
ProteomicsIdentification of a novel, tunable interface in the S.pombe HP1 protein, Swi6, that underpins epigenetic inheritance.
HP1 proteins bind dynamically to H3K9 methylation and are essential for establishing and maintaining transcriptionally silent epigenetic states, known as heterochromatin. HP1 proteins can dimerize, forming a binding interface that interacts with and recruits diverse chromatin-associated factors. HP1...
ORGANISM(S): Schizosaccharomyces pombe 
2024-08-10 | PXD047651 | Pride
Tmt-ms Epigenetics Quantip 
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