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MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
TranscriptomicsTranscription profiling of human proximal tubular epithelial cells inclubated with 5% plasma from septic patients or healthy volunteers
proximal tubular epithelial cell apoptosis were incubated with 5% plasma of septic patients or healthy volunteers diluited in RPMI 1640
ORGANISM(S): Homo sapiens 
2008-03-15 | E-MEXP-1510 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mono or co-cultured HMEC-1 and HK-2 cells to identify the influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells
The effect of the presence of HMEC-1 cells on HK-2 cell gene expression was investigated. Cells were cultured in mono or co-culture on opposite sides of aluminium oxide filters, 0.2 ?µM pore size. These conditions provide a close proximity but not direct contact. RNA from HK-2 cells was assayed with...
ORGANISM(S): Homo sapiens 
2008-02-05 | E-MEXP-1178 | biostudies-arrayexpress
TranscriptomicsRNA seq of fluid shear stress treated mouse renal epithelial cells
Renal epithelial cells are exposed to mechanical forces due to flow-induced shear stress within the nephrons. We applied RNA sequencing to get a comprehensive overview of fluid-shear regulated genes and pathways in the immortalized renal proximal tubular epithelial cell line. Cells were exposed to l...
ORGANISM(S): Mus musculus 
2018-03-15 | E-MTAB-6640 | biostudies-arrayexpress
TranscriptomicsRNA seq of fluid shear stress treated mouse Pkd1-/- renal epithelial cells
Pkd1-/- renal epithelial cells are exposed to mechanical forces due to flow-induced shear stress within the nephrons. We applied RNA sequencing to get a comprehensive overview of fluid-shear regulated genes and pathways in the immortalized Pkd1-/- renal proximal tubular epithelial cell line. Cells w...
ORGANISM(S): Mus musculus 
2019-03-01 | E-MTAB-6641 | biostudies-arrayexpress
GenomicsNLRP2 promotes proinflammatory and chemotactic responses in proximal tubular epithelial cells
NLRP2 promotes proinflammatory and chemotactic responses in proximal tubular epithelial cells
PRJNA507959 | ENA
TranscriptomicsTranscription profiling of human kidney glomerular and tubular progenitor cells
Multipotent progenitor cells (MPs) have been observed in human kidneys and particularly in Bowman's capsule and proximal tubules. The kidney owns the ability to repair local damage and renal MPs may play a role in the regenerative processes. Microarray technology was applied to identify differential...
ORGANISM(S): Homo sapiens 
2009-11-09 | E-GEOD-8611 | biostudies-arrayexpress
ProteomicsTime-series proteomic study of diabetic nephropathy in human proximal tubular epithelial HK-2 cells
Shotgun time-series proteomic analysis based on stable isotope dimethyl labeling and UHPLC-MS/MSC to relatively quantify the changes in protein expression of human proximal tubular HK-2 cells exposed to a diabetic-like microenvironment
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015102 | Pride
Proximal tubular cells Proteomics Hypoxia Hyperglycemia Diabetic nephropathy Hk-2 cells 
TranscriptomicsTranscription profiling of human renal proximal tubular cell line HK-2 treated with Cyclosporine A timecourse 0, 12, 48 hours
Effect of 4.2 micromolar Cyclosporine A on human renal proximal tubular cell line HK-2 over 48 hours
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1403 | biostudies-arrayexpress
GenomicsExpression data from Stx2-treated human renal proximal tubular epithelial cell (RPTEC)
Expression data from Stx2-treated human renal proximal tubular epithelial cell (RPTEC)
PRJNA723351 | ENA
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