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MetabolomicsThe patatin-like protein PlpD forms novel structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane

Members of the Omp85 superfamily of outer membrane proteins (OMPs) found in Gram-negative bacteria, mitochondria and chloroplasts are characterized by a distinctive 16-stranded β-barrel transmembrane domain and at least one periplasmic POTRA domain. All previously studied Omp85 proteins promote c...

2025-12-08 | MTBLS9803 | MetaboLights
MetabolomicsStaphylococcus aureus coagulases increase survival of Pseudomonas aeruginosa during coinfection

Polymicrobial infections involving Staphylococcus aureus are often more severe than single-species infections. S. aureus typically initiates the infection, creating conditions that allow secondary pathogens like Pseudomonas aeruginosa to establish. In this study, we investigate how coagulase prod...

2026-10-16 | MTBLS13310 | MetaboLights
MetabolomicsGenome-scale metabolic modelling of responses to polymyxins in Pseudomonas aeruginosa
Background: Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibiotics...
2018-02-28 | MTBLS630 | MetaboLights
MetabolomicsComparative metabolomics and transcriptomics revealed multiple pathways associated with polymyxin killing in Pseudomonas aeruginosa
Polymyxins are the last-line antibiotics against multidrug-resistant Pseudomonas aeruginosa however, resistance to polymyxins has been increasingly reported. Therefore, understanding the mechanisms of polymyxin activity and resistance is crucial for preserving their clinical usefulness. This study e...
2018-11-14 | MTBLS751 | MetaboLights
MetabolomicsUntargeted metabolomics reveals species-specific metabolite production and shared nutrient consumption by Pseudomonas aeruginosa and Staphylococcus aureus

While bacterial metabolism is known to impact antibiotic efficacy and virulence, the metabolic capacities of individual microbes in cystic fibrosis lung infections are difficult to disentangle from sputum samples. Here, we show that untargeted metabolomic profiling of supernatants of multiple str...

2021-05-26 | MTBLS2105 | MetaboLights
MetabolomicsMetabolic Phenotyping and Strain Characterisation of Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients Using Rapid Evaporative Ionisation Mass Spectrometry
Rapid evaporative ionisation mass spectrometry (REIMS) is a novel technique for the real-time analysis of biological material. It works by conducting an electrical current through a sample, causing it to rapidly heat and evaporate, with the analyte containing vapour channelled to a mass spectrometer...
2022-01-26 | MTBLS644 | MetaboLights
ProteomicsPseudomonas aeruginosa LC-MS/MS
Pseudomonas aeruginosa is a major cause of morbidity and mortality in patients with cystic fibrosis (CF). The P. aeruginosa CF isolate PASS4 has reduced ability to catabolise various carbon sources however can grow on DNA as a sole carbon source but, with a higher biomass production than P. aerugino...
ORGANISM(S): Pseudomonas aeruginosa 
2019-06-24 | PXD006742 | Pride
Pseudomonas aeruginosa lc-ms/ms 
OtherPseudomonas aeruginosa clinical isolates
35 P. aeruginosa clinical strains were cultivated under standard conditions, characterized in terms of virulence and biofilm phenotype, and their metabolomes were investigated by untargeted liquid chromatography-mass spectrometry.
ORGANISM(S): Pseudomonas Aeruginosa (ncbitaxon:287) 
2022-07-12 | MSV000089869 | MassIVE
ProteomicsThe examination of Pseudomonas aeruginosa proteome in the presence of phenolic acids
Pseudomonas aeruginosa, which is an important oppurtunistic pathogen, is a serious threat for human health, worldwide. New antimicrobial agents are in search and phenolic acids, secondary metabolites of plants, are promising candidates. In this project, the protein profile changes of Pseudomoas aeru...
ORGANISM(S): Escherichia coli 
2020-08-27 | PXD016243 | Pride
Phenolic acids Pseudomonas aeruginosa Antimicrobial action mechanism Lc-esi-ms/ms 
ProteomicsTriflic acid-treatment enables LC-MS/MS analysis of insoluble bacterial biomass
Established bacterial proteome sample preparations, including sonication and bead beating, leave insoluble carbohydrate-rich cell envelope pellets with an abundance of vital proteins often overlooked or missed in LC-MS/MS analyses. Triflic acid selectively removes glycans and we demonstrate that in ...
ORGANISM(S): Homo sapiens (Human) Pseudomonas aeruginosa PAO1 Bacillus subtilis 
2019-01-29 | PXD009004 | Pride
Lc-ms/ms Microbiome Bacteria Triflic acid 
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