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ProteomicsGTPase driven maturation of the human mitoribosomal peptidyl transferase center
We combine genetic perturbation with cryo-electron microscopy (cryo-EM) to establish the mechanism of PTC maturation during human mitoribosome biogenesis. Cryo-EM structures of large mitoribosomal subunit (mtLSU) assembly intermediates purified from GTPBP6-deficient cells reveal that GTPBP5 acts in ...
ORGANISM(S): Homo sapiens (Human) 
2021-05-20 | PXD023502 | Pride
Ptc maturation Gtpbp5 Gtpbp6 Mitochondrial ribosome Ribosome recycling Ribosome assembly Mterf4-nsun4 Mitoribosome Obg-hflx superfamily 
UnknownYjgA plays dual roles in enhancing PTC maturation.
Not available
S-EPMC11260487 | biostudies-literature
TranscriptomicsSAGE in Cultured Murine COC During Early Maturation
In cultured cumulus oocyte complexes (COC) FSH induces gene transcription required for germinal vesicle breakdown (GVBD). Experiments were performed to determine the critical period when gene transcription is required for GVBD and identify candidate mRNAs involved. Experiment I: murine COC were cult...
ORGANISM(S): Mus musculus 
2006-08-31 | E-GEOD-5568 | biostudies-arrayexpress
ProteomicsThe RNA helicase Dbp10 coordinates assembly factor association with PTC formation during ribosome biogenesis
During ribosome biogenesis a plethora of assembly factors and essential enzymes drive the unidirectional maturation of nascent pre-ribosomal subunits. The DEAD-box RNA helicase Dbp10 is suggested to restructure pre-ribosomal rRNA of the evolving peptidyl-transferase center (PTC) on nucleolar ribosom...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2024-05-22 | PXD046068 | Pride
Ribosome assembly. pre-60s Assembly factors S. cerevisiae 
UnknownThe RNA helicase Dbp10 coordinates assembly factor association with PTC maturation during ribosome biogenesis.
Not available
S-EPMC10899779 | biostudies-literature
TranscriptomicsEffects of in vitro maturation on oocyte gene expression
In vitro oocyte maturation (IVM) holds great promise as a tool for enhancing clinical treatment of infertility, enhancing availability of non human primates for development of disease models, and facilitating endangered species preservation. However, IVM outcomes have remained significantly below s...
ORGANISM(S): Macaca mulatta 
2009-05-20 | E-GEOD-11895 | biostudies-arrayexpress
TranscriptomicsGene expression during Arabidopsis flower maturation
Flower maturation consists of several events that contribute to reproductive success as flowers open, including petal expansion, stamen filament elongation, pollen release, nectary maturation, stigma growth, and gynoecium maturation to support pollen tube growth. The Arabidopsis transcription facto...
ORGANISM(S): Arabidopsis thaliana 
2011-12-10 | E-GEOD-32193 | biostudies-arrayexpress
TranscriptomicsMicroRNA-15/16 Antagonizes c-Myb to Control Natural Killer Cell Maturation
NK cells develop in the bone marrow and complete their maturation in peripheral organs, but the molecular events controlling maturation are incompletely understood. Utilizing an NK cell-specific miR-15/16 deficient genetic model (15aKO), we identified a critical role for miR-15/16 family microRNAs i...
ORGANISM(S): Mus musculus 
2015-09-03 | E-GEOD-55033 | biostudies-arrayexpress
UnknownPreclinical studies of gene replacement therapy for CDKL5 deficiency disorder.
Not available
S-EPMC11489525 | biostudies-literature
TranscriptomicsDendritic cell maturation by proinflammatory TNF or pathogenic Trypanosoma brucei antigens instruct similar T helper-2 cell responses in murine models of autoimmunity and asthma
Background Dendritic cells (DC) represent the major cell type leading to polarized T helper (Th) cell responses in vivo. The current data indicate that DC maturation under inflammatory conditions or by helminth infections induce only incomplete DC maturation bearing a partially tolerogenic potential...
ORGANISM(S): Mus musculus 
2012-03-19 | E-GEOD-28231 | biostudies-arrayexpress
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