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ProteomicsImmunoprecipitated PTPN22 Phosphoproteomics from Jurkat Cells
3x FLAG tagged PTPN22 were immunoprecipitated from Jurkat cells stimulated by TCR for 5min, and the proteins were eluted by FLAG peptides. This study aims to explore the phosphorylation sites on PTPN22 phosphatase, identifying two phosphorylation sites Ser325 and Ser449.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-21 | MSV000093717 | MassIVE
ProteomicsPhosphorylation sites of PTPN22 treated by Calyculin A in 293T cells
Phosphorylation sites of PTPN22 induced by Calyculin A treatment were identified by LC-MS
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD016103 | Pride
Ptpn22 phosphorylation 
GenomicsA novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling
A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling
PRJNA1102292 | ENA
ProteomicsGlobal phosphoproteomics for CRISPR/Cas9 mediated PTPN22 Ser325 mutagenesis on Jurkat cells
LQF of 3x FLAG PTPN22 WT Jurkat cells compared to S325A and S325E KI mutant Jurkat cells. WT or KI lines were stimulated with or without TCR engagement for 5 min.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-21 | MSV000093718 | MassIVE
GenomicsThe roles of Ptpn22 Ser452 phosphorylation in tumor-infiltrating CD8+ T cells from mouse
The roles of Ptpn22 Ser452 phosphorylation in tumor-infiltrating CD8+ T cells from mouse
PRJNA1095827 | ENA
TranscriptomicsA novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling
Protein Tyrosine Phosphatase Non-receptor type 22 (PTPN22) is encoded by a major autoimmunity gene and is a known inhibitor of T cell receptor (TCR) signaling and drug target for cancer immunotherapy. However, little is known about PTPN22 post-translational regulation. Here we characterize a phospho...
ORGANISM(S): Homo sapiens 
2024-07-17 | GSE264373 | GEO
TranscriptomicsThe roles of Ptpn22 Ser452 phosphorylation in tumor-infiltrating CD8+ T cells from mouse
Protein Tyrosine Phosphatase Non-receptor type 22 (PTPN22) is encoded by a major autoimmunity gene and is a known inhibitor of T cell receptor (TCR) signaling for cancer immunotherapy. However, little is known about PTPN22 phosphorylation in tumor infiltrating T cells. Here we characterize a phospho...
ORGANISM(S): Mus musculus 
2025-04-02 | GSE263092 | GEO
ProteomicsThe phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR
The protein tyrosine phosphatases (PTPs) TCPTP, PTPN22, and SHP1 are critical regulators of the activating phophotyrosine (pY) site on the initiating T cell kinase, LckY394, but the broader implications of these phophatases in T cell receptor (TCR) signalling and T cell biology remain unclear. By co...
ORGANISM(S): Homo sapiens (Human) 
2025-08-01 | PXD058624 | Pride
Shp1 Phosphoproteomics Tcptp Ptpn22 T cell signaling 
UnknownPTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling.
Not available
S-EPMC7263369 | biostudies-literature
UnknownNLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.
Not available
S-EPMC4855944 | biostudies-literature
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