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ProteomicsCustomizing functionalized cofactor mimics to study the human pyridoxal 5'-phosphate-binding proteome
Here we apply functionalized cofactor derivatives to study vitamin B6-dependent enzymes in human cells. We are able to cover for a large fraction of the pyridoxal 5'-phosphate-binding proteome (PLP-ome) and validate our results exemplarily for two PLP-DEs. One of those, named pyridoxal 5'-phosphate ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-27 | PXD014771 | Pride
Pyridoxal-probe Vitamin b6 antagonist Pyridoxal 5'-phosphate 
ProteomicsSLC25A38 is Required for Mitochondrial Pyridoxal 5’-Phosphate (PLP) accumulation
Many essential proteins require pyridoxal 5’-phosphate (PLP), the active form of vitamin B6, as a cofactor for activity including enzymes important for amino acid metabolism, one-carbon metabolism, polyamine synthesis, erythropoiesis, and neurotransmitter metabolism. A third of all mammalian PLP-...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058312 | Pride
Slc25a38 Mito ip Proliferation defects Lc-ms/ms 
UnknownChemoenzymatic synthesis of 1-deaza-pyridoxal 5'-phosphate.
Not available
S-EPMC3357107 | biostudies-literature
UnknownSLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation.
Not available
S-EPMC11760969 | biostudies-literature
ProteomicsBiochemical and proteomic studies on pyridoxal 5'-phosphate-binding protein (PLPBP)
Structural and proteomic investigations on conserved PLPBP.
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD015984 | Pride
Prosc Plpbp Pyridoxal 
UnknownPyridoxal 5'-Phosphate Biosynthesis by Pyridox-(am)-ine 5'-Phosphate Oxidase: Species-Specific Features.
Not available
S-EPMC10969823 | biostudies-literature
UnknownBiochemical and Proteomic Studies of Human Pyridoxal 5'-Phosphate-Binding Protein (PLPBP).
Not available
S-EPMC9558310 | biostudies-literature
UnknownNormal Cerebrospinal Fluid Pyridoxal 5'-Phosphate Level in a PNPO-Deficient Patient with Neonatal-Onset Epileptic Encephalopathy.
Not available
S-EPMC4486275 | biostudies-literature
UnknownCrystal structure of maize serine racemase with pyridoxal 5'-phosphate.
Not available
S-EPMC4774874 | biostudies-literature
UnknownBioisosteric replacement of pyridoxal-5'-phosphate to pyridoxal-5'-tetrazole targeting Bacillus subtilis GabR.
Not available
S-EPMC11669113 | biostudies-literature
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