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ProteomicsImproved data acquisition settings on Q Exactive HF-X Hybrid Quadrupole-Orbitrap and Orbitrap Fusion Lumos Tribrid mass spectrometers for proteomic analysis of limited samples
Deep proteomic profiling of complex biological and medical samples available at low nanogram and subnanogram levels is still challenging. To generate the most thorough and informative nanoflow liquid chromatography-tandem mass spectrometry-based proteomic profiling results for a limited sample analy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-07 | MSV000091218 | MassIVE
ProteomicsStroke Recovery Dominated by Dysregulation of Complement System – A Longitudinal Proteomics Pathway Analysis
Post-stroke recovery is an ongoing process as the brain attempts to reverse or minimize ischemia- induced disturbances in multiple biological systems. Currently, the longitudinal profile of molecular changes in patients post-stroke is relatively unknown. We therefore aimed to characterise biological...
ORGANISM(S): Homo sapiens (Human) 
2020-08-31 | PXD015006 | Pride
Stroke Human Edta plasma Blood Q exactive hf 
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
Proteomics: Robust and reproducible large-scale label-free deep quantitative profiling of the MOLM-14 surfaceome using three mass spectrometry platforms over multiple years
Surface proteins are one of the most important and common matrices for clinical chemistry and proteomic analyses. With the rapid developments in mass spectrometry (MS)-based proteomics methods, label-free quantitative proteomics has become an increasingly popular tool for profiling global protein ab...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD022721 | Pride
Quantitative proteomics Reproducibility Label-free quantification Mass spectrometry Surfaceome Large-scale 
ProteomicsParallel Reaction Monitoring on a Q Exactive Mass Spectrometer Increases Reproducibility of Phosphopeptide Detection in Bacterial Phosphoproteomics Measurements
Increasing number of studies report the relevance of protein Ser/Thr/Tyr phosphorylation in bacterial physiology, yet the analysis of this type of modification in bacteria still presents a considerable challenge. Unlike in eukaryotes, where tens of thousands of phosphorylation events likely occupy m...
ORGANISM(S): Escherichia coli 
2018-06-05 | PXD008211 | Pride
Lc-msms Phosphoproteomics Tio2 Prm E.coli Qexactive Dda 
ProteomicsThe fitness landscape of a Form II Rubisco in a photosynthetic bacterium guides engineering of oxygen tolerance
A pooled library of Synechocystis PCC6803 mutants expressing different RuBisCO variants were grown in turbidostats in different gas conditions and the proteome was analyzed by DIA LC/MS proteomics with a Q Exactive HF mass spectrometer after 0, 4 and 8 generations of growth
ORGANISM(S): Synechocystis sp. PCC 6803 
2026-07-16 | PXD071825 | Pride
Synechocystis Machine learning Cyanobacteria Rubisco Carbon fixation Enzyme engineering 
UnknownMetabolomics Analysis of PK-15 Cells with Pseudorabies Virus Infection Based on UHPLC-QE-MS.
Not available
S-EPMC9229976 | biostudies-literature
ProteomicsIdentification by Shotgun Proteomics with Q-Exactive Hybrid Quadripole-Orbitrap High Resolution Tandem Mass-Spectrometry, Histone isoforms’ Hypermethylation Phenotype as A Hallmark Characteristic of Human-IDH-Mutant High-Grade Gliomas
Histone variant-post-translational modifications (PTMs) have been allied to various pathological processes, especially in cancer-onset, envisaged as obvious epigenetic biomarkers-based genotoxicity and as predictors for pathological diagnosis and prognosis. Consequently, their mapping and characteri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-14 | MSV000093865 | MassIVE
MetabolomicsMetabolomic Profiling of Personalized Cancer Therapy Responses in Organoid Chips

This study investigates metabolomic changes associated with personalized cancer therapy responses in patient-derived organoid chips containing a reconstructed tumor microenvironment. The dataset includes de-identified sample metadata, raw mass spectrometry files, processed metabolite abundance ma...

2026-08-06 | MTBLS15195 | MetaboLights
UnknownDifferential plasma proteomes of the patients with Opisthorchiasis viverrini and cholangiocarcinoma identify a polymeric immunoglobulin receptor as a potential biomarker.
Not available
S-EPMC9562451 | biostudies-literature
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