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ProteomicsON-TISSUE DIRECT MONITORING OF GLOBAL HYDROGEN/DEUTERIUM EXCHANGE BY MALDI MASS SPECTROMETRY: TDXMS
Hydrogen/deuterium exchange mass spectrometric methods for protein structural analysis are conventionally performed in solution. We present Tissue Deuterium Exchange Mass Spectrometry (TDXMS), a method to directly monitor deuterium uptake on tissue, as a means to better approximate the deuterium exc...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-08-15 | PXD004630 | Pride
Tissue Mass spectrometry In situ analysis H/d exchange 
ProteomicsIntegrated Mass Spectrometry Imaging and Omics Workflows on the Same Tissue Section Using Parafilm-Assisted Microdissection
In this work, we demonstrate the use of grid-aided, parafilm-assisted microdissection to perform MALDI MS imaging and shotgun proteomics and metabolomics in a combined workflow and using only a single tissue section. The grid is generated by microspotting of acid dye 25 using a piezoelectric microsp...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-03-20 | PXD005345 | Pride
Proteomics Lipidomics Maldi ms imaging Parafilm-assisted microdissection 
ProteomicsTemporally & Spatially-Resolved Microproteomics and MALDI MSI Lipidomic Analysis for Traumatic Brain Injury
Using an experimental TBI rat model of mild/moderate Controlled Cortical Impact (CCI) injury, we combined large-scale proteomics identification and relative quantification using Spatially-Resolved Microproteomics with MALDI MS Imaging of Lipids. Spatially by studying ...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-06-19 | PXD011262 | Pride
Spatiotemporal microproteomics Macrophage Traumatic brain injury Long-chain acylcarnitine Astrocyte Substantia nigra 
ProteomicsReal-time molecular diagnosis of tumors using water-assisted laser desorption/ionization mass spectrometry technology
This dataset contains MS imaging raw data as well as the SCiLS file used to confirm the regions in dog sarcoma biopsies classified by the SpiderMass system after analysis of the consecutive tissue section. All the tissues were gathered during dog sarcoma surgeries, snap-frozen and analysed later in ...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2019-04-12 | PXD010990 | Pride
Molecular signatures Sarcoma Real-time Cancer Non-invasive Diagnostic Laser microprobe Spidermass Surgery Ambient ionization mass spectrometry 
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