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TranscriptomicsPDE-4 inhibition alters gene expression and improves INH-mediated clearance of Mtb in rabbit lungs
Tuberculosis kills nearly 2 million people through out the world, every year. The outcome of M. tuberculosis infection is determined by the host and bacterial factors. A strong host immune response controls the growth of the bacilli effectively. However, in a host with suboptimal immune response,...
ORGANISM(S): Oryctolagus cuniculus 
2011-03-16 | E-GEOD-27992 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of V. cholerae genes differentially expressed in rabbit ileal loop fluid and mucus
This SuperSeries is composed of the following subset Series: GSE6217: Microarray analysis of V. cholerae genes differentially expressed in 12 h rabbit ileal loop fluid GSE24405: Microarray analysis of V. cholerae genes differentially expressed in 8 h rabbit ileal loop mucus GSE24406: Microarray anal...
ORGANISM(S): Vibrio cholerae 
2010-09-28 | E-GEOD-24408 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of V. cholerae genes differentially expressed in 8h rabbit ileal loop fluid.
Transcriptional analysis of wild-type V. cholerae isolated from the rabbit ileal loop was performed by quickly pelleting bacteria from the fluid accumulated in the ileal loops after 8 h of infection. The bacteria were then resuspended in Trizol reagent and frozen on dry ice. The wild-type bacteria f...
ORGANISM(S): Vibrio cholerae 
2010-09-28 | E-GEOD-24407 | biostudies-arrayexpress
TranscriptomicsSpontaneous Latency in a Rabbit Model of Pulmonary Tuberculosis
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is an exquisitely adapted human pathogen capable of surviving for decades in the lungs of immune competent individuals in absence of disease. The World Health Organization estimates that 2 billion people have latent TB infec...
ORGANISM(S): Oryctolagus cuniculus 
2012-07-10 | E-GEOD-39219 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of V. cholerae genes differentially expressed in 12 h rabbit ileal loop mucus
The mucus and cell-associated bacteria were isolated as a single fraction from ileal loops twelve hours post inoculation by scraping the epithelial surface of the intestine with a disposable plastic cell scraper after the loops had been cut open and gently rinsed in PBS buffer to wash away remaining...
ORGANISM(S): Vibrio cholerae 
2010-09-28 | E-GEOD-24406 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of V. cholerae genes differentially expressed in 8 h rabbit ileal loop mucus
The mucus and cell-associated bacteria were isolated as a single fraction from ileal loops eight hours post inoculation by scraping the epithelial surface of the intestine with a disposable plastic cell scraper after the loops had been cut open and gently rinsed in PBS buffer to wash away remaining ...
ORGANISM(S): Vibrio cholerae 
2010-09-28 | E-GEOD-24405 | biostudies-arrayexpress
TranscriptomicsKinetics of progressive pulmonary cavitary TB disease in rabbits
Every year, tuberculosis kills nearly 1.8 million people through out the world. Though outcome of M. tuberculosis infection into active disease is determined by the host and bacterial factors, a strong host immune response controls the growth of the bacilli effectively. However, in a host with su...
ORGANISM(S): Oryctolagus cuniculus 
2011-12-07 | E-GEOD-33094 | biostudies-arrayexpress
ProteomicsHepatitis C-like viruses are produced in cells from rabbit and hare DNA
Hepatitis C virus (HCV), a major causative agent of acute and chronic liver disease, belongs to the Flaviviridæ family and contains a single-strand positive-sense RNA genome, which upon virus entry and uncoating, functions as mRNAs and thus can be directly translated into proteins by host cell machi...
ORGANISM(S): Hepatitis C virus 
2016-01-21 | PXD001992 | Pride
Rhcv Rabbit Hhcv Dna Hare Hcv Maldi-tof/tof 
TranscriptomicsA Model System for Studying the Transcriptomic and Physiological Changes Associated with Mammalian Host-Adaptation by Leptospira interrogans Serovar Copenhageni
Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by spirochetes belonging to the genus Leptospira. More than 500,000 cases of severe leptospirosis are reported annually, with .10% of these being fatal. Leptospires can survive for weeks in suitably moist conditions b...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2014-03-20 | E-GEOD-53818 | biostudies-arrayexpress
TranscriptomicsEarly innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits
In our rabbit model of pulmonary tuberculosis, infection with Mtb HN878, a hyper-virulent W-Beijing strain, results in progressive cavitary disease. However, infection of rabbit lungs with Mtb CDC1551, a hyper-immunogenic strain is effectively controlled overtime, establishing latent Mtb infection....
ORGANISM(S): Oryctolagus cuniculus 
2013-08-17 | E-GEOD-49947 | biostudies-arrayexpress
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