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MetabolomicsLong-term low-dose ionizing radiation induced chromosome-aberration-specific metabolic phenotype changes in radiation workers

Long-term low-dose ionizing radiation (LLIR) widely exists in human life and has been confirmed to have potential pathogenic effects on cancer and cardiovascular diseases. However, it is technically and ethically unfeasible to explore LLIR-induced phenotypic changes in the human cohort, leading t...

2022-04-07 | MTBLS3854 | MetaboLights
TranscriptomicsGene expression signatures that predict radiation exposure (mouse)
Gene expression analysis of peripheral blood leukocytes (PB MNCs) to develop expression profiles that accurately reflect prior radiation exposure. Keywords: Comparative, exposure dosage, C57BI6 Murine Irradiation Studies We have made use of gene expression analysis of peripheral blood mononuclear ce...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-6873 | biostudies-arrayexpress
TranscriptomicsNatural Cubic Spline Regression Modeling Followed by Dynamic Network Reconstruction for the Identification of Radiation-Sensitivity Gene Association Networks from Time-course Transcriptome data.
Time course gene-expression profiling was conducted in human lymphoblastoid cell lines (LUCY) after exposure with 1Gy and 10Gy gamma irradiation. Differentially expressed genes were identified using natural cubic spline regression modeling (NCSRM) and subsequently subjected to gene regulatory networ...
ORGANISM(S): Homo sapiens 
2016-06-11 | E-MTAB-4829 | biostudies-arrayexpress
TranscriptomicsGene expression signatures that predict radiation exposure
This SuperSeries is composed of the following subset Series: GSE6871: Gene expression signatures that predict radiation exposure (human) GSE6873: Gene expression signatures that predict radiation exposure (mouse) Keywords: SuperSeries Refer to individual Series
ORGANISM(S): Mus musculus 
2010-06-12 | E-GEOD-6874 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Norwegian spruce embryos exposed to gamma radiation
Conifers such as Picea abies (Norway spruce) are among the most radiosensitive plant species, yet the molecular impact of ionising radiation on their stem cells remains poorly understood. This study examines the transcriptomic response of embryogenic stem cells to gamma radiation, focusing on mechan...
ORGANISM(S): Picea abies 
2025-07-14 | E-MTAB-15297 | biostudies-arrayexpress
ProteomicsInhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair
Glioblastoma (GBM) is the most lethal brain tumour that occurs in adults and treatment for GBM has been largely unsuccessful. Ionizing radiation (IR) and chemotherapeutic agents are employed as standard of care treatment for GBM patients and both result in DNA damage. Previous data identified phosph...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-08-07 | MSV000081423 | MassIVE
TranscriptomicsMicroarray profiles of radiation response in the NCI60 cell lines
The 60 cell lines of the NCI Anti-Cancer Drug Screen (NCI60) constitute the most extensively characterized in vitro cancer cell model, and have been tested for sensitivity to over 100,000 potential chemotherapy agents. We have used the NCI60 cell lines and three additional lymphoblast lines to deve...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-7505 | biostudies-arrayexpress
TranscriptomicsExposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland
Six to eight week old female C57BL/6J mice were exposed to 2 Gy of whole body γ radiation and mammary glands were surgically removed 2-month after radiation. RNA was isolated and microarray hybridization performed for gene expression analysis. 5 samples were analyzed: 2 controls at 2 months, 1 2 Gy ...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-57196 | biostudies-arrayexpress
TranscriptomicsTrancription profiling of breast tumor biopsies to identify markers of Taxane Sensitivity in Breast Cancer
The purpose of this study was to identify molecular markers of pathologic response to neoadjuvant paclitaxel/radiation treatment, protein and gene expression profiling were done on pretreatment biopsies. Patients with high-risk, operable breast cancer were treated with three cycles of paclitaxel fo...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-22513 | biostudies-arrayexpress
TranscriptomicsDietary flaxseed- and radiation-sensitive microRNAs in murine lung
Murine lung miRNAs were profiled by rodent TaqMan OpenArray after flaxseed feeding and/or radiation exposure Lung tissue was obtained 48 hours after radiation or no exposure from three animals each: flaxseed/no radiation, flaxseed/radiation, control diet/no radiation, control diet/radiation. miRNA p...
ORGANISM(S): Mus musculus 
2014-04-29 | E-GEOD-57123 | biostudies-arrayexpress
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