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ProteomicsThe metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex - DATA SET II
Mitochondria are essential organelles that play a key role in energy metabolism. Transitions between glycolytic and respiring conditions induce considerable adaptations of the cellular proteome. These metabolism-dependent changes are particularly pronounced for the protein composition of mitochondri...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-15 | PXD036508 | Pride
Mitochondrial import Ubc8 Yeast metabolism 
ProteomicsSperm motility annotated genes: are they associated with impaired fecundity?
To determine whether Gene Ontology sperm motility annotated genes are differentially abundant in sperm collected from men with oligoasthenozoospermia and to gain further insight into molecular mechanisms underlying male infertility
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD033749 | Pride
Fertility Sperm motility 
ProteomicsProteomic landscape of human spermatozoa in patients with different spermatogenic impairments
Infertility is a widespread problem, affecting around 15% of couples worldwide, and is defined as the inability to achieve pregnancy within one year despite unprotected intercourse 1. Infertility can be caused by either male or female reproductive issues. Various medical conditions including maligna...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-05-10 | PXD039703 | Pride
Sperm Infertility 
ProteomicsA priority code in mitochondrial presequences - Data set 2: Proteome of WT and CNS1 mutant yeast strains
The biogenesis of mitochondria relies on the import of hundreds of different precursor proteins from the cytosol. Most of these proteins are synthesized with N-terminal presequences which serve as mitochondrial targeting signals. Presequences consistently form amphipathic helices, but they considera...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-09 | PXD059975 | Pride
Mitochondria Yeast 
ProteomicsInteractome of NbdA containing nanodiscs
Studies of membrane protein-protein interactions are very important to fully understand the biological function of a cell. The solubilization of proteins from the native membrane environment is a critical step in the preparation of membrane proteins that might affect the stability of protein complex...
ORGANISM(S): Escherichia coli 
2023-07-20 | PXD039700 | Pride
Dibma polymer Nanodiscs 
ProteomicsProteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer. Dataset 2
Aneuploidy is prevalent in cancer, conferring fitness advantage, multidrug resistance, and poor prognosis. In contrast, experimentally induced aneuploidy often results in adverse effects and impaired proliferation. This paradox underscores the necessity of cancer cells to adapt to abnormal chromosom...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD049124 | Pride
Cancer Aneuploidy Evolution Lc-ms/ms 
ProteomicsProteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer. Dataset 1
Aneuploidy is prevalent in cancer, conferring fitness advantage, multidrug resistance, and poor prognosis. In contrast, experimentally induced aneuploidy often results in adverse effects and impaired proliferation. This paradox underscores the necessity of cancer cells to adapt to abnormal chromosom...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD049120 | Pride
Cancer Aneuploidy Evolution Lc-ms/ms 
ProteomicsProteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer. Dataset 3
Aneuploidy is prevalent in cancer, conferring fitness advantage, multidrug resistance, and poor prognosis. In contrast, experimentally induced aneuploidy often results in adverse effects and impaired proliferation. This paradox underscores the necessity of cancer cells to adapt to abnormal chromosom...
ORGANISM(S): Homo sapiens (Human) 
2025-01-14 | PXD056432 | Pride
Cancer Aneuploidy Evolution Lc-ms/ms 
ProteomicsA priority code in mitochondrial presequences - Data set 1: IPs from rabbit reticulocyte lysates
The biogenesis of mitochondria relies on the import of hundreds of different precursor proteins from the cytosol. Most of these proteins are synthesized with N-terminal presequences which serve as matrix targeting signals. Presequences consistently form amphipathic helices, but they considerably dif...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-09 | PXD053210 | Pride
Yeast mitochondrial import 
ProteomicsElectroneutral polymer nanodiscs enable interference-free probing of membrane proteins in a lipid-bilayer environment
Membrane proteins can be examined in near-native lipid-bilayer environments with the advent of polymer-encapsulated nanodiscs. These nanodiscs self-assemble directly from cellular membranes, allowing in vitro probing of membrane proteins with techniques that had previously been restricted to soluble...
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD030958 | Pride
Membrane proteins Dibma nanodiscs 
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