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ProteomicsChromatin-bound proteins co-localized with CTCF during mES cell neuronal differentiation
Using Chromatin immunoprecipitation combined with Selective Isolation of Chromatin Associated Proteins (ChIP-SICAP), we define the chromatin-bound proteins co-localized with CTCF in mouse embryonic stem cells (ES) and neuronal stem (NS) cells. We uncover the proteins that are differentially co-local...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-13 | PXD048470 | Pride
Chip-sicap Ctcf Rna-binding proteins Chromatin 
UnknownThyroid endocrine status and biochemical stress responses in adult male Wistar rats chronically exposed to pristine polystyrene nanoplastics.
Not available
S-EPMC8142327 | biostudies-literature
ProteomicsIdentification of chromatin-associated proteins occupying the promoter region of CDKN1A
The p21 protein, encoded by CDKN1A, plays a vital role in the induction of senescence, and its transcriptional control by p53 tumour supressor is well-established. However, p21 can also be regulated in a p53-independent manner, by mechanisms that remain poorly understood. Therefore, we here used a c...
ORGANISM(S): Homo sapiens (Human) 
2021-09-07 | PXD022542 | Pride
Cdkn1a Znf84 Chromatin-associated proteins 
ProteomicsInverted chromatin immunoprecipitation identifies Tcf1 as a negative regulator of Foxp3 expression
Regulatory T (Treg) cells are important regulators of the immune system and have versatile functions for the homeostasis and repair of tissues. They express the forkhead box transcription factor Foxp3 as a lineage-defining protein. In mature Treg cells, the Foxp3 core promoter is unmethylated indica...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD018764 | Pride
T-cell factor 1 (tcf1) Foxp3-promoter Regulatory t (treg) cells 
TranscriptomicsTrim24 knock down in the 2i-state of the mouse ES cells
Differentially expressed genes were determined by single-end sequencing (stranded protocol) following Trim24 and/or p53 knock down in the mouse ES cells grown in 2i media. Triplicates were generated for treatment and control samples but for p53 knock down (duplicate).
ORGANISM(S): Mus musculus 
2017-11-08 | E-MTAB-4893 | biostudies-arrayexpress
TranscriptomicsRNAseq of HCT116 p53KO cells transfected with either siRNA silencing ZNF84 or with negative control siRNA, in 2 variants of experiment a) with doxorubicin treatment (doxorubicin added 48h post-transfection, for the next 48h before harvesting) b) untreated, cultured 72h post-transfection
The aim of this experiments was to characterise the transcriptomic changes occurring in cancer cells, in which ZNF84 gene is silenced, in control conditions and when cells undergo stress by being treated with cytostatic doses of doxorubicin. We anticipated that ZNF84 regulates the level of p21 cell ...
ORGANISM(S): Homo sapiens 
2021-05-05 | E-MTAB-9848 | biostudies-arrayexpress
TranscriptomicsiCLIP of Dazl in mouse embryonic stem cells
In this experiment we would like to identify the binding sites of Dazl on the transcriptome of mESCs. To do that, we carried out an iCLIP experiment using mESCs grown in 2iL condition.
ORGANISM(S): Mus musculus 
2020-12-25 | E-MTAB-9332 | biostudies-arrayexpress
UnknownRNA polymerase II-associated proteins reveal pathways affected in VCP-related amyotrophic lateral sclerosis.
Not available
S-EPMC7614746 | biostudies-literature
GenomicsChIP-Seq of Dazl in mouse embryonic stem cells
We developed a method to identify chromatin-associated proteins by mass spectrometry. In addition to many known DNA and chromatin-binders, we identified several RNA-binding proteins in the chromatin composition of mouse embryonic stem cells (mESC). Interestingly, we found Dazl as a RBP that specific...
ORGANISM(S): Mus musculus 
2020-12-25 | E-MTAB-9302 | biostudies-arrayexpress
UnknownImpacts of Sodium/Glucose Cotransporter-2 Inhibitors on Circulating Uric Acid Concentrations: A Systematic Review and Meta-Analysis.
Not available
S-EPMC8872662 | biostudies-literature
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