Sort   by:  
 Page size 
TranscriptomicsMicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.
microRNAs in the miR-106b family are overexpressed in multiple tumor types and are correlated with the expression of genes that regulate the cell cycle. Consistent with these observations, miR-106b family gain of function promotes cell cycle progression, whereas loss of function reverses this phenot...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-14831 | biostudies-arrayexpress
ProteomicsIdentification of chromatin-associated proteins occupying the promoter region of CDKN1A
The p21 protein, encoded by CDKN1A, plays a vital role in the induction of senescence, and its transcriptional control by p53 tumour supressor is well-established. However, p21 can also be regulated in a p53-independent manner, by mechanisms that remain poorly understood. Therefore, we here used a c...
ORGANISM(S): Homo sapiens (Human) 
2021-09-07 | PXD022542 | Pride
Cdkn1a Znf84 Chromatin-associated proteins 
TranscriptomicsTAF15 protein regulates CDKN1A through miRNAs
TAF15 (formerly TAFII68) is a member of the TET family of RNA and DNA binding proteins whose genes are frequently translocated in sarcomas. Consistent with a functional role in cell viability, TAF15 depletion had a growth-inhibitory effect and increased apoptosis. Interestingly, one of the genes aff...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-34470 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of metastatic lung cancer cell lines
During malignant disease progression, the extracellular matrix (ECM) of epithelial tumors accumulates inter-molecular cross-links between collagen strands; these cross-links enhance ECM stiffness and trigger tumor cell invasion and dissemination, but the mechanisms that regulate intra-tumoral collag...
ORGANISM(S): Mus musculus 
2015-03-12 | E-GEOD-49315 | biostudies-arrayexpress
TranscriptomicsRing1B Promotes Hepatic Stem/Progenitor Cell Expansion via Simultaneous Suppression of Cdkn1a and Cdkn2a
The expansion of hepatic stem/progenitor cells requires Ring1B-mediated epigenetic silencing of Cdkn1a and Cdkn2a, demonstrating that Ring1B simultaneously regulates multiple CDKI in tissue stem/progenitor cells. Comparison of gene expression profiles between Ring1B KO and WT murine liver cells at E...
ORGANISM(S): Mus musculus 
2014-04-01 | E-GEOD-54116 | biostudies-arrayexpress
GenomicsCDKN1A Deficiency in Zebrafish Promote Follicle Maturation and Degeneration Mediated by CRISPR/Cas9 Targeted Disruption
CDKN1A Deficiency in Zebrafish Promote Follicle Maturation and Degeneration Mediated by CRISPR/Cas9 Targeted Disruption
PRJNA1000445 | ENA
TranscriptomicsDual role of EZH2 on megakaryocyte differentiation, analysis at different stages of maturation at day 9 of culture
EZH2, the enzymatic component of PRC2, has been identified as a key factor in hematopoiesis. EZH2 loss of function mutations have been found in myeloproliferative neoplasms, more particularly in myelofibrosis, but the precise function of EZH2 in megakaryopoiesis is not fully delineated. Here, we sho...
ORGANISM(S): Homo sapiens 
2021-11-02 | E-MTAB-8610 | biostudies-arrayexpress
GenomicsHighly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21
Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21
PRJNA766853 | ENA
ProteomicsCDKN1A stabilizes Cyclin D3 by inhibiting its phosphorylation-dependent nuclear export following butyrate treatment
Butyrate-mediated inhibition of cell proliferation is part of the preventive role of dietary fiber against colorectal cancer (CRC). This effect notably involves the cyclin-dependent kinase inhibitor CDKN1A in human intestinal cells, yet the underlying molecular mechanisms remain incompletely underst...
ORGANISM(S): Homo sapiens (Human) 
2026-02-12 | PXD062450 | Pride
Lc-ms/ms Butyrate Homo sapiens Cyclin 
TranscriptomicsTAF15 protein regulates CDKN1A through miRNAs
TAF15 (formerly TAFII68) is a member of the TET family of RNA and DNA binding proteins whose genes are frequently translocated in sarcomas. Consistent with a functional role in cell viability, TAF15 depletion had a growth-inhibitory effect and increased apoptosis. Interestingly, one of the genes aff...
ORGANISM(S): Homo sapiens 
2012-12-21 | GSE34470 | GEO
Sort   by:  
 Page size