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ProteomicsThe impact of oncogenic EGFRvIII on the proteome of extracellular vesicles (exosomes) released from glioblastoma cells
Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary brain tumors, driven by a complex repertoire of oncogenic alterations, including the constitutively active epidermal growth factor receptor (EGFRvIII). EGFRvIII impacts both cell-intrinsic and non-cell autonomous ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-30 | PXD008311 | Pride
Glioblastoma Exosomes Cancer Glioma Extracellular vesicles Heterogeneity Egfrviii Nano-flow cytometry Oncogene Invasion 
ProteomicsImmune cell infiltration into brain tumor microenvironment is mediated by Rab27-regulated vascular wall integrity
Aggressive brain tumors often exhibit immunologically ‘cold’ microenvironment, where the vascular barrier impedes effective immunotherapy in poorly understood ways. Tumor vasculature also plays a pivotal role in immunoregulation and antitumor immunity. Here we show that small GTPase Rab27 controls t...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-02 | PXD062939 | Pride
Brain tumor Adoptive immunity Cytotoxic t-cells Glioma Vasculature Blood brain barrier Endothelial cells Tight junctions. Tumor microenvironment 
ProteomicsAngiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells
Glioblastoma multiforme (GBM) is an aggressive, heterogeneous and highly vascularized brain tumor. GBM is thought to arise from glioblastoma stem-like cells (GSCs) which are characterized as being either proneural or mesenchymal. The former isolates of GSCs are tight sphere forming and slow growing ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD034819 | Pride
Glioblastoma stem cells Endothelial cells Extracellular vesicles Glioblastoma Heterogeneity Mesenchymal Invasion Migration Proneural 
TranscriptomicsComparative transcriptomic analysis of human and Drosophila extracellular vesicles reveals extensive conservation
Extracellular vesicles (EVs) are membrane-enclosed nanoparticles containing specific repertoires of genetic material. In mammals, EVs can mediate the horizontal transfer of various cargos and signaling molecules, notably miRNA and mRNA species. Whether this form of intercellular communication prevai...
ORGANISM(S): Homo sapiens 
2016-06-15 | E-GEOD-76173 | biostudies-arrayexpress
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