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Transcriptomics17beta-estradiol (E2)-regulated gene expression across time in estrogen-dependent and estrogen deprivation-resistant MCF-7-derived breast cancer cell lines.
A series of MCF-7 variants were previously developed that are either estrogen-dependent for growth (MCF-7:WS8 cells), or resistant to estrogen deprivation and refractory (MCF-7:2A) or sensitive (MCF-7:5C) to E2-induced apoptosis. To identify genes associated with E2-induced apoptosis, estrogen depri...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-29917 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of 2 SCCOHT PDX models and the SCCOHT cell lines BIN67 and SCCOHT1
Transcriptional profiling of 2 SCCOHT patient-derived xenograft (PDX) models and 2 SCCOHT cell lines compared to normal ovary to investigate underlying biology of SCCOHT. RNA from 2 SCCOHT PDXs and 2 SCCOHT cell lines were individually hybridized with a pool of 2 commercial normal ovary RNA on Agile...
ORGANISM(S): Homo sapiens 
2015-08-28 | E-GEOD-66434 | biostudies-arrayexpress
ProteomicsProteomic analysis of the human milieu of gamete /embryo maternal interaction
The improvement of the embryo culture media is of high relevance due to its influence on successful implantation rates, pregnancy, neonatal outcomes and potential effects in the adult life. The ideal conditions for embryo development are those naturally occurring in the female reproductive tract, i....
ORGANISM(S): Homo sapiens (Human) 
2019-10-29 | PXD015980 | Pride
Low abundance proteins  human reproductive fluids  salpingectomy 
ProteomicsNeddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed developmentally down-regulated protein 8, to target proteins, with yet-unknown consequences. Here we show in mice that neddylation in liver is modulated by nutrient availability. ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-08 | PXD043054 | Pride
Pck1 Neddylation Glucose 
TranscriptomicsSmall Cell Carcinoma of the Ovary (SCCO) vs. Normal Ovary
Transcriptional profiling of 4 SCCO tumors compared to age-matched normal ovary to investigate underlying tumor biology and potential therapeutic targets. RNA from 4 SCCO fresh-frozen tumors were individually hybridized to a pool of 2 commercial normal ovary RNA on Agilent 44K v2 human gene expressi...
ORGANISM(S): Homo sapiens 
2014-01-17 | E-GEOD-49887 | biostudies-arrayexpress
TranscriptomicsOvarian Cancer: 19 ovarian tumors of diverse histologic type vs. pool of all 19 tumors.
Transcriptional profiling of 19 ovarian tumors of 5 distinct histologic types (serous, endometrioid, clear cell, mucinous and small cell), to investigate similar and distinct biology associated with each histologic type. RNA from fresh-frozen ovarian tumor samples were individually hybridized to a p...
ORGANISM(S): Homo sapiens 
2014-01-17 | E-GEOD-49888 | biostudies-arrayexpress
Transcriptomics29 untreated breast cancer cell lines vs. pool of all 29 cell lines.
Expression profiling of 29 untreated breast cancer cell lines using Agilent 4x44K V1 (G4112F) dual color oligonucleotide microarrays The primary study objective was to establish a research resource for comparative transcriptomic analysis of a series of commercially available breast cancer cell lines...
ORGANISM(S): Homo sapiens 
2013-11-27 | E-GEOD-51086 | biostudies-arrayexpress
TranscriptomicsIdentification of gene regulation patterns underlying both E2- and tamoxifen-stimulated cell growth through global gene expression profiling in breast cancer cells [MCF-7]
A c-Src inhibitor blocks estrogen (E2)-induced stress and converts E2 responses from inducing apoptosis to growth stimulation in E2-deprived breast cancer cells. A reprogrammed cell line, MCF-7:PF, results with features of functional estrogen receptor (ER) and over-expression of insulin-like growth ...
ORGANISM(S): Homo sapiens 
2014-07-18 | E-GEOD-59536 | biostudies-arrayexpress
UnknownPhenotype-Agnostic Molecular Subtyping of Neurodegenerative Disorders: The Cincinnati Cohort Biomarker Program (CCBP).
Not available
S-EPMC7578373 | biostudies-literature
UnknownA Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia.
Not available
S-EPMC7722692 | biostudies-literature
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