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TranscriptomicsDifferentially expressed Transcribed ultraconserved regions (T-UCRs) in Crohn's disease (CD) comparing to normal controls (NC)
To date, 481 transcribed ultraconserved regions (T-UCRs) have been discovered in human genome. We aimed to investigate their characteristics in Crohn’s disease (CD) with conparison to healthy normal controls, to reveal differentially expressed T-UCRs. 3 CD patients and 3 NC volunteers were recruit...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-83982 | biostudies-arrayexpress
TranscriptomicsRIP: miR-202 mimic-transfected HeLa cells vs. negative control
Potential miR-202 targets were identified using a targetome-wide RIP-based microarray. HeLa cells were transfected with either a miR-202 mimic or a scrambled single-stranded RNA negative control. RNA was isolated from total cell lysate prior to IP and from antibody-immobilized Protein G agarose be...
ORGANISM(S): Homo sapiens 
2012-12-19 | E-GEOD-42981 | biostudies-arrayexpress
ProteomicsNovel insights into quantitative proteomics from an innovative bottom-up Simple Light Isotope Metabolic (bSLIM) labeling data processing strategy
The Simple Light Isotope Metabolic labeling (SLIM-labeling) is an inovative method to quantify proteome variations based on an original in vivo labeling strategy. Heterotrophic cells grown on a U-[12C] sole source of carbon synthesize U-[12C]-amino acids which are incorporated into proteins giving r...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-15 | PXD021329 | Pride
Openms Data processing workflow Yeast In vivo metabolic labeling Light carbon isotope Quantitative proteomics 12c Knime 
TranscriptomicsShifting of immune responsiveness to house dust mite by influenza a infection genomic insights
House dust mite (HDM) extract (Greer Laboratories, Lenoir, NC) was resuspended in sterile phosphate-buffered saline (PBS) at a concentration of 0.5 mg (protein)/ml and 10 ul (5 ug dose) was administered to isofluorane-anesthetized mice intranasally. Groups of mice were infected either with influenza...
ORGANISM(S): Mus musculus 
2011-08-16 | E-MEXP-3325 | biostudies-arrayexpress
ProteomicsTraining set - Novel insights into quantitative proteomics from an innovative bottom-up Simple Light Isotope Metabolic (bSLIM) labeling data processing strategy
The Simple Light Isotope Metabolic labeling (SLIM-labeling) is an inovative method to quantify proteome variations based on an original in vivo labeling strategy. Heterotrophic cells grown on a U-[12C] sole source of carbon synthesize U-[12C]-amino acids which are incorporated into proteins giving r...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-16 | PXD021502 | Pride
Openms Data processing workflow Yeast In vivo metabolic labeling Light carbon isotope Quantitative proteomics 12c Knime 
TranscriptomicsNF-kB target genes in dendritic cells
The ability of dendritic cells (DC) to initiate immunity and induce antigen-specific tolerance makes DC ideal targets for pharmacological intervention into immune responses. NF-kB factors are a family of transcriptional regulators important for DC development and function. However, the identity of N...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-8009 | biostudies-arrayexpress
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
ProteomicsHigh throughput screen of 100,000 small molecules in C9orf72 ALS neurons
Background. An intronic G4C2 repeat expansion in the C9orf72 gene is the major known cause for Amyotrophic Lateral Sclerosis. There is evidence forthree possible disease mechanisms: a pathological gain of function of nuclear repeat RNA foci, repeat associated noncanonical (RAN) translation into toxi...
ORGANISM(S): Homo sapiens (Human) 
2025-03-07 | PXD034016 | Pride
Als Srsf1 C9orf72 
ProteomicsHigh throughput screen of 100,000 small molecules in C9orf72 ALS neurons dataset2
Background. An intronic G4C2 repeat expansion in the C9orf72 gene is the major known cause for Amyotrophic Lateral Sclerosis. There is evidence forthree possible disease mechanisms: a pathological gain of function of nuclear repeat RNA foci, repeat associated noncanonical (RAN) translation into toxi...
ORGANISM(S): Homo sapiens (Human) 
2025-03-07 | PXD034092 | Pride
C9orf72 Spliceosome Als 
ProteomicsHigh throughput screen of 100,000 small molecules in C9orf72 ALS neurons dataset3
Background. An intronic G4C2 repeat expansion in the C9orf72 gene is the major known cause for Amyotrophic Lateral Sclerosis. There is evidence forthree possible disease mechanisms: a pathological gain of function of nuclear repeat RNA foci, repeat associated noncanonical (RAN) translation into toxi...
ORGANISM(S): Homo sapiens (Human) 
2025-03-07 | PXD034093 | Pride
C9orf72 Spliceosome Als 
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