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TranscriptomicsGene expression of murine B cells activated via TLR4 or TLR4 + CD40: Group1 naM-CM-/ve B cells, Group2 LPS activated B cells 24h, Group3 LPS + anti-CD40 activated B cells 24h, Group4 LPS activated B cells 72h, and Group5 LPS + anti-CD40 activated B cells 72h.
Murine B cells can be activated via the surface receptors TLR4 and CD40. For a global assessment of differences in gene expression between these two different modes of B cell activation a genome wide transcriptome analysis was performed. In order to dissect different gene expression profiles of B ce...
ORGANISM(S): Mus musculus 
2014-02-24 | E-GEOD-35998 | biostudies-arrayexpress
ProteomicsUbiquitylation-omics analysis on WWP2 overexpressed mouse tubular epithelial cells (MPTCs)
WWP2 is a E3 ubiquitin ligase which may be implicated in multiple cellular event. WWP2 expressed in the kidneys and its pathological role remain to be elucidated. We performed this ubiquitylation omics analysis on renal tubular epithelial cells which overexpressd WWP2 to study WWP2's potential ubiqu...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD048540 | Pride
Renal tubular epithelial cells Ubiquitylation-omics 
ProteomicsQuantitative proteinomics on WWP2 overexpressed human tubular epithelial cells HK-2
WWP2 is a E3 ligase which regulates multiple cellular events, such as stress response, differentiation. WWP2 played physiological role in the distal tubules of the kidneys. Whether WWP2 regulated pathophysiological rol in the proximal tubules is unclear. In the present study, we stably overexpressed...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD048622 | Pride
Human tubular epithelial cells Wwp2 Proteinomics 
ProteomicsSequential Glycosylations at the Multibasic Cleavage Site of SARS-CoV-2 Spike Protein Regulate Viral Activation, Assembly, and Infection
The multibasic furin cleavage site at the S1/S2 boundary of the spike protein (S protein) is a hallmark of SARS-CoV-2 and plays an crucial role in viral infection. O-glycosylation near the furin site catalyzed by host cell glycosyltransferases can theoretically hinder spike protein processing and im...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD049110 | Pride
Sars-cov-2 O-glycosylation Galnac-t7 Viral assembly 
UnknownThe prevalence of social care in US health care settings depends on how and whom you ask.
Not available
S-EPMC7260787 | biostudies-literature
UnknownMolecular design of thermally activated delayed fluorescent emitters for narrowband orange-red OLEDs boosted by a cyano-functionalization strategy.
Not available
S-EPMC8278966 | biostudies-literature
UnknownDevelopment of Prognostic Prediction Model to Estimate Mortality for Frail Oldest Old: Prospective Cohort Study.
Not available
S-EPMC10061936 | biostudies-literature
TranscriptomicsTranscription profiling of responses to TNF-alpha, IL-1beta, peptidoglycan or lipopolysaccharide (TLR2/4 agonists) evaluated at 4 hrs in peripheral blood monocytes (PBM) from the patient bearing the IRAK4 Q293X mutation vs PBM from 5 healthy individuals
IL-1R associated kinase-4 (IRAK4) is a key enzyme required for activation of the common Toll-like Receptor (TLR) signaling cascade, which results in the transcription of inflammatory and immunity genes. IRAK-4 deficiency has recently been described as a rare form of innate immunodeficiency. Patien...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-FPMI-7 | biostudies-arrayexpress
UnknownBionic nanovesicles sequentially treat flaps with different durations of ischemia by thrombolysis and prevention of ischemia-reperfusion injury
Not available
S-EPMC11846944 | biostudies-literature
TranscriptomicsTranscription profiling of human monocytic cells THP-1 stimulated with LPS (10ng/ml) in presence or absence of LL-37 (5 ug/ml), as well as with the peptide alone, for 4 hours
The objective of the study was to evaluate transcriptional response of endotoxin-stimulated human monocytic cells in presence or absence of host defense peptide LL-37 at low physiologically relevant concentrations. Human monocytic cells THP-1 were stimulated with LPS (10ng/ml) in presence or absenc...
ORGANISM(S): Homo sapiens 
2006-12-07 | E-FPMI-6 | biostudies-arrayexpress
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