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ProteomicsCD68+ region of rat scar tissue by AutoSTOMP
To test the ability of the Automated Spatially Targeted Optical Micro Proteomics (AutoSTOMP) protocol to selectively biotinylate structures of interest within tissue sections we first examined a rat myocardial infarction model. In this model, trauma caused by ligation and infiltrating immune cells c...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-08-10 | PXD026818 | Pride
Macrophage Rat cardiac scar Autostomp 
TranscriptomicsProtective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling
1.1 Introduction Cardiac fibrosis occurs in a wide range of cardiac diseases and is characterised by the transdifferentiation of cardiac fibroblasts into myofibroblasts these cells produce large quantities of extracellular matrix, resulting in myocardial scar. The profibrotic process is m...
ORGANISM(S): Homo sapiens 
2024-11-30 | E-MTAB-14602 | biostudies-arrayexpress
ProteomicsSpatially-targeted optical microproteomics timecourse of rat myocardial infarction
Myocardial infarction (MI) results from occlusion of blood supply to the heart muscle causing death of cardiac muscle cells. Following myocardial infarction (MI), scar formation acts to mechanically stabilise the injured heart to prevent rupture and death. While fibroblasts and macrophages are impli...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-31 | PXD034413 | Pride
Cardiac Heart Macrophage Cd68 Rat Sma Microproteomics Fibroblast Myocardial infarction 
TranscriptomicsGenome-wide profiling of gene expression under electro-acupuncture treatment on MI heart in rats
Purpose: Acupuncture exerts cardioprotective effects on several types of cardiac injuries, especially myocardial ischemia (MI). In order to elucidate the potential mechanisms, RNA-seq by next generation sequencing was used to identify the rat genome-wide alterations after MI and EA treatment in t...
ORGANISM(S): Rattus norvegicus 
2016-03-21 | E-GEOD-54132 | biostudies-arrayexpress
UnknownIntravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodelling by increasing elastin expression in cardiac scar tissue after myocardial infarction.
Not available
S-EPMC3105227 | biostudies-literature
UnknownThe Goto Kakizaki rat: Impact of age upon changes in cardiac and renal structure, function.
Not available
S-EPMC8224913 | biostudies-literature
TranscriptomicsMicroRNA Expression in Rat Myocardial Infarction intervened by propranolol
We established a rat model of myocardial Infarction by performing a surgical operation of left anterior descending coronary artery occlusion under sterie conditions. Wistar rats were previously randomly divided into 4 groups: control, ischemia, ischemia-propranolol, and non-ischemia-propranolol. Our...
ORGANISM(S): Rattus norvegicus 
2010-06-19 | E-GEOD-18129 | biostudies-arrayexpress
TranscriptomicsMicrocurrent-Mediated Modulation of Myofibroblasts for Cardiac Repair and Regeneration
Myofibroblasts are one of the key cell types in cardiac injuries, leading to scar tissue formation and reduced heart function. To investigate the impact of microcurrent treatment on these cells, primary rat cardiac fibroblasts were initially differentiated into myofibroblasts. Subsequently, the diff...
ORGANISM(S): Rattus norvegicus 
2024-03-14 | GSE238154 | GEO
UnknownCardiac regeneration using human-induced pluripotent stem cell-derived biomaterial-free 3D-bioprinted cardiac patch in vivo.
Not available
S-EPMC7254497 | biostudies-literature
UnknownA self-locking conductive cardiac patch for immediate electrical integration with infarcted rat myocardium.
Not available
S-EPMC12630037 | biostudies-literature
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