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TranscriptomicsSingle cell transcriptomics analysis of induced pluripotent stem cell-derived cortical neurons reveals frequent dual layer identity
Induced pluripotent stem cell (iPSC)-derived cortical neurons present a powerful new model of neurological disease. Previous work has established that differentiation protocols produce cortical neurons but little has been done to characterise these at cellular resolution. In particular, it is unclea...
ORGANISM(S): Homo sapiens 
2016-01-08 | E-GEOD-69790 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat primary cortical neurons exposed to anesthetics
Inhaled anesthetics produce many effects and bind to a large number of brain proteins, but it is not yet clear if this is accompanied by widespread changes in gene expression of the biological targets. Such changes in expression might implicate functionally important targets from the large pool of ...
ORGANISM(S): Rattus norvegicus 
2008-05-07 | E-GEOD-2982 | biostudies-arrayexpress
TranscriptomicsPHF6 knockdown in rat cortical neurons
E18 embryonic rat cortical neurons cultured in vitro are infected with lentivirus expressing control or PHF6shRNA-2, and harvested 5 days after infection pLL3.7 lentivirus expressing control or PHF6shRNA-2 was generated in 293T cells and concentrated using ultracentrifuge. In vitro cultured cortical...
ORGANISM(S): Rattus norvegicus 
2013-08-01 | E-GEOD-45953 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat control subplate neurons with few synapses and cocultured subplate neurons with induced synaptogenesis
The transcriptional events accompanying synaptogenesis are largely unknown, or have been studied in systems in which synapse formation occurs gradually over time. With a system in which synaptogenesis is synchronized and controllable, molecular or biochemical techniques can be used to examine cellu...
ORGANISM(S): Rattus norvegicus 
2008-11-29 | E-GEOD-8318 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat depolarization induced gene from primary cortical neuron
Activation of neurons is one of the fundamental events for the functioning of nervous system. Neuronal activation relays information to next neurons. On the other hand, the activated neurons themselves are also influenced by neuronal activation. Depending on the type and condition of neuronal activa...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-4472 | biostudies-arrayexpress
TranscriptomicsExpression profiles of primary cortical neurons after knocking down Fus
To clarify the functional properties of FUS, we established the differentially expressed alternative exons in FUS-silenced primary cortical neurons by using exon-sensitive microarray technology. We analyzed total RNA of primary cortical neuron infected with lentivirus expressing shRNA against mouse ...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-36153 | biostudies-arrayexpress
ProteomicsRat Cortical Primary Neuronal Culture with NRN1 Protein Treatment
Cortical rat neuronal culture, lysis and proteolytic digestion Primary rat cortical neurons were generated from E18 Sprague-Dawley rat embryos with minor modifications (Swanger, Mattheyses et al. 2015, Henderson, Greathouse et al. 2019). Neurons were cultured at a density of 4x105 cells per well in...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-07-20 | PXD040867 | Pride
Rat primary cortical neurons Nrn1 Neuroproteomics 
ProteomicsIdentifying interactors through BioID2 in rat cortical neurons
Utilizing proximity labeling technolgy coupled to LC-MS/MS to identify TTBK1 and TTBK2 unique interactors in rat cortical neurons
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-06 | PXD017937 | Pride
Neurons Proteomics Bioid2 Interactors 
TranscriptomicsModulation of gene expression by complement protein C1q in amyloid-beta injured neurons
Complement protein C1q is induced after injury in the brain and during Alzheimer's disease and has been shown to protect against amyloid-beta induced neuronal death. In this study, we used microarray approach to identify the pathways modulated by C1q that are associated with neuroprotection. Immatur...
ORGANISM(S): Rattus norvegicus 
2012-12-21 | E-GEOD-28886 | biostudies-arrayexpress
TranscriptomicsCHD5, A Brain-Specific Chromatin Remodeling Enzyme, Regulates Expression Of Neuronal Genes.
CHD5 is frequently deleted in neuroblastoma, and appears to be a tumor suppressor gene; however, little is known about the role of CHD5. We found CHD5 mRNA was restricted to brain; by contrast most other remodeling ATPases were broadly expressed. CHD5 protein isolated from mouse brain was associat...
ORGANISM(S): Rattus norvegicus 
2011-09-21 | E-GEOD-27620 | biostudies-arrayexpress
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