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ProteomicsTwenty-four hour rhythms in the absence of the clock gene Bmal1
Circadian (~24 hour) clocks exist in almost all types of living organism and play a fundamental role in regulating daily physiological and behavioural processes. The transcription factor BMAL1 (ARNTL) is thought to be one of the principal drivers of the molecular clock in mammals since its deletion ...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD009243 | Pride
Bmal1  circadian rhythms  kinase network  non-transcriptional oscillators  rhythmic proteome and phosphoproteome 
ProteomicsSingle-cell transcriptomics and cell-specific proteomics reveals new molecular regulators of sleep
Every day, we sleep for a third of the day. Sleep is important for cognition, brain waste clearance, metabolism, and immune responses. Homeostatic regulation of sleep is maintained by progressively rising sleep need during wakefulness, which then dissipates during sleep. The molecular mechanisms gov...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD018334 | Pride
Phosphoproteomics Differential proteomics Tandem mass tag Sleep deprivation Neuron Strocyte Single-cell rna sequencing Brainstem Hypothalamus Cortex 
ProteomicsPhenotypic Proteomic Profiling Reveals Convergent Kinase Targets for Circadian Clock Modulators
Determining the mechanisms of action of drug molecules that modulate circadian rhythms is critical to develop novel compounds to treat clock disorders. Here we employed Phenotypic Proteomic Profiling (PPP) integrating multipronged proteomics approaches including global proteome, phosphoproteome, kin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD014186 | Pride
Circadian rhythms  circadian period altering compounds  kinase  phenotypic proteome profiling  phosphoproteome  proteomics  thermal proteome profiling 
MetabolomicsRhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells (LC-MS)

Circadian clocks coordinate mammalian behaviour and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs), which do not contain a nucleus, and cannot perfor...

2020-11-13 | MTBLS1285 | MetaboLights
MetabolomicsRhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells (GC-MS)

Circadian clocks coordinate mammalian behaviour and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs), which do not contain a nucleus, and cannot perfor...

2020-11-13 | MTBLS1286 | MetaboLights
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