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MetabolomicsUntargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides. Eflornithine, a polyamine pathway inhibitor, and nifurtimox, whose mode of action involves its metabolic activation, are ...
2017-06-07 | MTBLS459 | MetaboLights
UnknownMassive Gastrointestinal Bleeding from a Jejunal Dieulafoy Lesion: An Extraordinary Presentation.
Not available
S-EPMC6940470 | biostudies-literature
TranscriptomicsMolecular and phenotypic characterization of a mouse model of oculopharyngeal muscular dystrophy reveals severe muscular atrophy restricted to fast glycolytic fibres
Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset disorder characterized by ptosis, dysphagia and proximal limb weakness. Autosomal-dominant OPMD is caused by a short (GCG)8–13 expansions within the first exon of the poly(A)-binding protein nuclear 1 gene (PABPN1), leading to an expanded p...
ORGANISM(S): Mus musculus 
2011-01-14 | E-GEOD-26604 | biostudies-arrayexpress
UnknownAgromorphological and Physiological Performance of Ethiopian Common Bean (Phaseolus vulgaris L.) Genotypes under Different Agroecological Conditions.
Not available
S-EPMC10305400 | biostudies-literature
ProteomicsHeading towards a dead end: the role of DND1 in germ line differentiation of human iPSCs
The DND microRNA-mediated repression inhibitor 1 (DND1) is a conserved RNA binding protein (RBP) and plays an important role in survival and maintenance of primordial germ cells (PGCs) and the development of the male germline in zebrafish and mice. It was shown to be expressed in human pluripotent s...
ORGANISM(S): Homo sapiens (Human) 
2021-12-10 | PXD023802 | Pride
Primordial germ cells Proteomics Mass spectrometry Dnd1 Differentiation Human pluripotent stem cells 
ProteomicsPabpn1-driven cytoskeletal rearrangement induces muscle wasting
Poly(A) binding protein nuclear 1 (PABPN1) is a multifunctional regulator of mRNA processing. PABPN1 inhibits alternative polyadenylation (APA), and in conditions with reduced PABPN1 levels APA utilization causes genome-wide mRNA dysregulation. PABPN1 levels decline from midlife onwards in Oculophar...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD004865 | Pride
Pfn1 Pabpn1 Mouse Csrp3 Progenesis Lfq Murc 
UnknownA slice of pi : an exploratory neuroimaging study of digit encoding and retrieval in a superior memorist.
Not available
S-EPMC4323087 | biostudies-literature
UnknownPrognostic implications of ultra-short heart rate variability indices in hospitalized patients with infective endocarditis.
Not available
S-EPMC10289432 | biostudies-literature
ProteomicsRegulation of dendritic cells and macrophages by an anti-apoptotic cell natural Ab that inhibits inflammatory arthritis
Although natural antibodies (NAbs) are present from birth, little is known about what drives their selection, and whether they have housekeeping functions. We now show that the prototypic T15-NAb, first identified because of its protective role in infection, is representative of a previously unknown...
ORGANISM(S): unidentified 
2010-05-06 | E-GEOD-14969 | biostudies-arrayexpress
UnknownRacial and socioeconomic disparities in lung cancer screening in the United States: A systematic review.
Not available
S-EPMC8266751 | biostudies-literature
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