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GenomicsChIP-seq analysis of E2FA, E2FB, E2FC and RBR targets
ChIP-seq analysis of E2FA, E2FB, E2FC and RBR targets
PRJNA903916 | ENA
ProteomicsCullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain
RING-Between-RING (RBR) E3 ligases mediate ubiquitin transfer through an obligate E3- ubiquitin thioester intermediately prior to substrate ubiquitination. While RBRs share a conserved catalytic module, substrate recruitment mechanisms remain enigmatic and the relevant domains have yet to be identi...
ORGANISM(S): Homo sapiens (Human) 
2023-05-24 | PXD030849 | Pride
Kojak Cross-linking mass spectrometry Proxl Skyline Cullin Xl-ms Hhari Ubiquitin Rbr E3 ligase 
ProteomicsQuantitative XL-MS Analysis of HHARI in the presence or absence of 4EHP
RING-Between-RING (RBR) E3 ligases mediate ubiquitin transfer through an obligate E3- ubiquitin thioester intermediately prior to substrate ubiquitination. While RBRs share a conserved catalytic module, substrate recruitment mechanisms remain enigmatic and the relevant domains have yet to be identi...
ORGANISM(S): Homo Sapiens 
2024-07-26 | PXD030871 | panorama
ProteomicsNoncanonical assembly, neddylation, and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
Ubiquitin ligation is typically executed by hallmark E3 catalytic domains. Two such domains, "cullin-RING" and "RBR", are individually found in several hundred E3 ligases in humans, and collaborate with E2 enzymes to catalyze ubiquitylation. However, the vertebrate-specific CUL9 complex with RBX1 (a...
ORGANISM(S): Homo sapiens (Human) 
2024-04-09 | PXD047229 | Pride
Ubiquitin Rbx1 Tp53 Apex2 Nedd8 Rbr Cullin Cul9 E3-ligase 
ProteomicsMapping RNA interactions of human ATRX with RepA fragment of Xist
Heterochromatin in the eukaryotic genome is rigorously controlled by the concerted action of protein factors and RNAs. Here, we investigate the RNA binding function of ATRX, a chromatin remodeler with roles in silencing of repetitive regions of the genome and in recruitment of the polycomb repressi...
ORGANISM(S): Homo sapiens (Human) 
2020-03-09 | PXD017806 | Pride
Rbrid  rna-protein interactions  rna-binding 
TranscriptomicsTranscription profiling by array of Arabidopsis wild type and RETINOBLASTOMA-RELATED (RBR) RNAi plants (late timepoints)
RNA was labeled and hybridized to ATH1 arrays.
ORGANISM(S): Arabidopsis thaliana 
2010-12-14 | E-TABM-919 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Arabidopsis wild type and RETINOBLASTOMA-RELATED (RBR) RNAi plants (early timepoints)
RNA was labeled and hybridized to ATH1 arrays.
ORGANISM(S): Arabidopsis thaliana 
2010-12-14 | E-TABM-918 | biostudies-arrayexpress
GenomicsChIP-seq analysis of E2FA, E2FB, E2FC and RBR targets
The goal of the experiment was to identify and compare at the genome-wide level the targets of E2FA, E2FB and E2FC, the three canonical E2Fs, and those of their binding partner RBR.
ORGANISM(S): Arabidopsis thaliana 
2023-08-06 | GSE218481 | GEO
UnknownThe ring between ring fingers (RBR) protein family.
Not available
S-EPMC1868946 | biostudies-literature
UnknownRBR E3-ligases at work.
Not available
S-EPMC3989860 | biostudies-literature
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