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ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery. Here we probe the effects of catalytic inhibition on the proximity of CAMKK2. The experiment was supervised by Sabrina Keller and Viviane Reber. This project is part of the IMI ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD058412 | Pride
Bioid 
ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery. Here we probe the effects of catalytic inhibition on the proximity of CAMKK2. The experiment was supervised by Sabrina Keller and Viviane Reber. This project is part of the IMI ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD058418 | Pride
Bioid 
ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery. Here we probe the effects of catalytic inhibition of CAMKK2 on the proximity of PRKAA1. The experiment was supervised by Sabrina Keller and Viviane Reber. This project is part o...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD058471 | Pride
Bioid 
ProteomicsParadoxical non-catalytic kinase functions are driven by inhibitor-induced displacement of autoinhibitory domains
Protein kinases are crucial regulators of cellular processes, and their dysregulation is frequently associated with human disorders. ATP-competitive type I inhibitors are widely used to block aberrant kinase activity. However, their effect on non-catalytic kinase functions such as conformation and p...
ORGANISM(S): Homo sapiens (Human) 
2026-06-17 | PXD069830 | Pride
Lip-ms Proximity labeling Structural proteomics Ap-ms Bioid 
ProteomicsLiP-MS on HEK293 lysate treated with Probe Candidate TR05481366 and Negative Control TR05302201
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating lysate with the drug of interest, which induces structural changes such as occupation of the binding site or chan...
ORGANISM(S): Homo sapiens (Human) 
2023-09-01 | PXD041100 | Pride
Target engagement profiling Lip-ms 
ProteomicsLiP-MS on Purified CAMKK1 treated with Staurosporine
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating protein with the drug of interest, which induces structural changes such as occupation of the binding site or cha...
ORGANISM(S): Homo sapiens (Human) 
2023-04-26 | PXD041089 | Pride
Target engagement Lip-ms 
ProteomicsLiP-MS on HEK293 lysate treated with Probe Candidate TR05267290 and Negative Control TR05706192
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating lysate with the drug of interest, which induces structural changes such as occupation of the binding site or chan...
ORGANISM(S): Homo sapiens (Human) 
2023-09-01 | PXD041098 | Pride
Target engagmenet profiling Lip-ms 
ProteomicsLiP-MS on HEK293 lysate treated with Probe Candidate TR06189215 and Negative Control TR03633723
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating lysate with the drug of interest, which induces structural changes such as occupation of the binding site or chan...
ORGANISM(S): Homo sapiens (Human) 
2023-04-26 | PXD041099 | Pride
Target engagmenet profiling Lip-ms 
ProteomicsLiP-MS on DCLK1 Purified from HEK293 cells treated with DCLK1-IN-1
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating lysate with the drug of interest, which induces structural changes such as occupation of the binding site or chan...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD055350 | Pride
Chemical probe Lip-ms 
ProteomicsLiP-MS on CAMK1 Purified from HEK293 cells treated with CS640
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating lysate with the drug of interest, which induces structural changes such as occupation of the binding site or chan...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD058292 | Pride
Chemical probe Lip-ms 
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