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ProteomicsProteomics of liver from ob/ob and WT mice
Proteomics of liver tissue from ob/ob and WT mice. Data accompany our paper entitled “Dynamic Regulation of N6,2′-O-dimethyladenosine (m6Am) in Obesity” scheduled for publication in Nature Communications, 2021
ORGANISM(S): Mus musculus (Mouse) 
2021-10-27 | PXD029217 | Pride
Mouse Liver Ob/ob 
ProteomicsProteomics of liver from mice fed high fat diet (HFD) or regular chow diet
Proteomics of liver tissue from mice fed a high fat diet (HFD) or regular chow diet. Data accompany our paper entitled “Dynamic Regulation of N6,2′-O-dimethyladenosine (m6Am) in Obesity” scheduled for publication in Nature Communications, 2021
ORGANISM(S): Mus musculus (Mouse) 
2021-10-27 | PXD029280 | Pride
Mouse Liver High fat diet 
ProteomicsProteomics of HEPG2 cells following FTO overexpression and knockdown
Proteomics of HEPG2 cells following FTO overexpression and knockdown. Data accompany our paper entitled “Dynamic Regulation of N6,2′-O-dimethyladenosine (m6Am) in Obesity” scheduled for publication in Nature Communications, 2021
ORGANISM(S): Homo sapiens (Human) 
2021-10-27 | PXD029268 | Pride
Human Hepg2 Fto 
Transcriptomicsm1A marks translation initiation sites in human and mouse messenger RNA [Sequencing]
We developed a novel approach, m1A-seq, for high-resolution mapping of the transcriptome-wide m1A landscape, based on antibody-mediated capture followed by massively parallel sequencing Identification of m1A modified sequences in human, mouse and yeast cell lines
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-70485 | biostudies-arrayexpress
TranscriptomicsTemporal transcriptional profiling of polyamine-depleted NIH3T3 cells
Polyamines are absolutely required for cell growth and proliferation. While polyamine depletion results in reversible cell cycle arrest, the actual mechanism of growth inhibition is still obscure. This work aimed at determining the cellular processes affected by reduction in the intracellular polyam...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-36445 | biostudies-arrayexpress
Transcriptomicsm6A mapping in human RNA (untreated)
We developed a novel approach, m6A-seq, for high-resolution mapping of the transcriptome-wide m6A landscape, based on antibody-mediated capture followed by massively parallel sequencing. Identification of m6A modified sequences in HepG2 cells.
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37003 | biostudies-arrayexpress
Transcriptomicsm1A marks translation initiation sites in human and mouse messenger RNA [microarray]
We developed a novel approach, m1A-seq, for high-resolution mapping of the transcriptome-wide m1A landscape, based on antibody-mediated capture followed by massively parallel sequencing. Using this method we performed immunodepletion of methylated transcipts to assess the average methylation level I...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-76057 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Downs syndrome with acute lymphoblastic pediatric leukemia (DS-ALL) patients
DS-ALL is a highly heterogeneous disease with predominance of an aberrant exp. of CRLF2 cooperating with mutated JAK2; Acute lymphoblastic pediatric leukemia specimens of Down's syndrome are examined for gene expression profiles and specific genetic aberrations. Gene expression profiling and specifi...
ORGANISM(S): Homo sapiens 
2010-01-15 | E-GEOD-17459 | biostudies-arrayexpress
TranscriptomicsPharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis
The search for developmental mechanisms driving vertebrate organogenesis has paved the way toward a deeper understanding of birth defects. During embryogenesis, parts of the heart and craniofacial muscles arise from pharyngeal mesoderm (PM) progenitors. Here, we reveal a hierarchical regulatory netw...
ORGANISM(S): Mus musculus 
2012-11-26 | E-GEOD-42389 | biostudies-arrayexpress
TranscriptomicsAlu sequences in undifferentiated human embryonic stem cells display high levels of A-to-I RNA editing
Adenosine to Inosine (A-to-I) RNA editing is a site-specific modification of RNA transcripts, catalyzed by members of the ADAR (Adenosine Deaminase Acting on RNA) protein family. RNA editing occurs in human RNA in thousands of different sites. Some of the sites are located in protein-coding regions ...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-19719 | biostudies-arrayexpress
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