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ProteomicsStructural mapping of the surfaces of fibrillar 1N3R and 1N4R human tau
The structural characterization of pathogenic tau filaments that accumulate in tauopathies, including Alzheimer disease, is key for understanding their pathogenic function and identify the structural determinants of distinct tau filaments involved in distinct tauopathies. Fibrillar tau surfaces play...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027403 | Pride
Structural proteomics  proteolysis  chemical surface modification  nhs-biotin  nanolc-msms Tau fibrils 
ProteomicsStructure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies (Part 1)
The aggregation of the protein alpha-synuclein (αSyn) is a common feature of multiple neurodegenerative diseases collectively called synucleinopathies, for which the pathobiology is not well understood. The different phenotypic characteristics of the synucleinopathies Parkinson’s disease (PD), Demen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD058124 | Pride
Synucleopathies Structural proteomics  mass spectrometry  chemical surface modification  nhs-biotin  nanolc-msms Amplified synuclein fibrils 
ProteomicsIdentification of proteins interacting with extracellularly applied α-syn assemblies, Condition 3 - controls (5/8)
Fibrillar α-Synuclein (α-Syn) is the principal component of Lewy bodies which are evident in individuals affected by Parkinson disease (PD). This neuropathologic form of α-Syn contributes to PD progression and propagation of exogeneous α-Syn between neurons has been demonstrated. In order to identif...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-07 | PXD002260 | Pride
Lc-msms Oligomers Fibrils Pull-down Protein-protein interactions Proteomics Alpha-synuclein 
ProteomicsIdentification of proteins interacting with extracellularly applied α-syn assemblies, Condition 1 - biological replicates (2/8)
Fibrillar α-Synuclein (α-Syn) is the principal component of Lewy bodies which are evident in individuals affected by Parkinson disease (PD). This neuropathologic form of α-Syn contributes to PD progression and propagation of exogeneous α-Syn between neurons has been demonstrated. In order to identif...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-07 | PXD002257 | Pride
Lc-msms Oligomers Fibrils Pull-down Protein-protein interactions Proteomics Alpha-synuclein 
ProteomicsIdentification of proteins interacting with extracellularly applied α-syn assemblies, Condition 2 - controls (3/8)
Fibrillar α-Synuclein (α-Syn) is the principal component of Lewy bodies which are evident in individuals affected by Parkinson disease (PD). This neuropathologic form of α-Syn contributes to PD progression and propagation of exogeneous α-Syn between neurons has been demonstrated. In order to identif...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-07 | PXD002258 | Pride
Lc-msms Oligomers Fibrils Pull-down Protein-protein interactions Proteomics Alpha-synuclein 
ProteomicsIdentification of proteins interacting with extracellularly applied α-syn assemblies, Condition 3 - biological replicates (6/8)
Fibrillar α-Synuclein (α-Syn) is the principal component of Lewy bodies which are evident in individuals affected by Parkinson disease (PD). This neuropathologic form of α-Syn contributes to PD progression and propagation of exogeneous α-Syn between neurons has been demonstrated. In order to identif...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-07 | PXD002261 | Pride
Lc-msms Oligomers Fibrils Pull-down Protein-protein interactions Proteomics Alpha-synuclein 
ProteomicsIdentification of proteins interacting with extracellularly applied α-syn assemblies, Condition 1 - controls (1/8)
Fibrillar α-Synuclein (α-Syn) is the principal component of Lewy bodies which are evident in individuals affected by Parkinson disease (PD). This neuropathologic form of α-Syn contributes to PD progression and propagation of exogeneous α-Syn between neurons has been demonstrated. In order to identif...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-07 | PXD002256 | Pride
Lc-msms Oligomers Fibrils Pull-down Protein-protein interactions Proteomics Alpha-synuclein 
ProteomicsIdentification of proteins interacting with extracellularly applied α-syn assemblies, Condition 4 - controls (7/8)
Fibrillar α-Synuclein (α-Syn) is the principal component of Lewy bodies which are evident in individuals affected by Parkinson disease (PD). This neuropathologic form of α-Syn contributes to PD progression and propagation of exogeneous α-Syn between neurons has been demonstrated. In order to identif...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-07 | PXD002262 | Pride
Lc-msms Oligomers Fibrils Pull-down Protein-protein interactions Proteomics Alpha-synuclein 
ProteomicsIdentification of proteins interacting with extracellularly applied α-syn assemblies, Condition 4 - biological replicates (8/8)
Fibrillar α-Synuclein (α-Syn) is the principal component of Lewy bodies which are evident in individuals affected by Parkinson disease (PD). This neuropathologic form of α-Syn contributes to PD progression and propagation of exogeneous α-Syn between neurons has been demonstrated. In order to identif...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-07 | PXD002263 | Pride
Lc-msms Oligomers Fibrils Pull-down Protein-protein interactions Proteomics Alpha-synuclein 
ProteomicsIdentification of proteins interacting with extracellularly applied α-syn assemblies, Condition 2 - biological replicates (4/8)
Fibrillar α-Synuclein (α-Syn) is the principal component of Lewy bodies which are evident in individuals affected by Parkinson disease (PD). This neuropathologic form of α-Syn contributes to PD progression and propagation of exogeneous α-Syn between neurons has been demonstrated. In order to identif...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-07 | PXD002259 | Pride
Lc-msms Oligomers Fibrils Pull-down Protein-protein interactions Proteomics Alpha-synuclein 
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