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ProteomicsAnticancer effect of deuterium depleted water - comprehensive proteomics analysis suggests a redox disbalance mechanism
The proteomics data is derived from 4 parts of samples prepared and analysed by nanoLC-MS/MS. In order to make appropriate statistical analysed could be performed, all treatments were performed in biological replicates. The number of replicates was 4 for protein abundances analysis (part 1), 2 for t...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD011085 | Pride
Anticancer Proteomics Redox disbalance Deuterium depleted water 
UnknownAnticancer Effect of Deuterium Depleted Water - Redox Disbalance Leads to Oxidative Stress.
Not available
S-EPMC6885702 | biostudies-literature
UnknownMAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD.
Not available
S-EPMC9817175 | biostudies-literature
UnknownRedox status, DNA and HSA binding study of naturally occurring naphthoquinone derivatives.
Not available
S-EPMC7003638 | biostudies-literature
UnknownInterrelation between miRNAs Expression Associated with Redox State Fluctuations, Immune and Inflammatory Response Activation, and Neonatal Outcomes in Complicated Pregnancy, Accompanied by Placental Insufficiency.
Not available
S-EPMC9854567 | biostudies-literature
UnknownNOX4-derived ROS are neuroprotective by balancing intracellular calcium stores.
Not available
S-EPMC10119225 | biostudies-literature
UnknownDifferential Response of Two Tomato Genotypes, Wild Type cv. Ailsa Craig and Its ABA-Deficient Mutant flacca to Short-Termed Drought Cycles.
Not available
S-EPMC8617711 | biostudies-literature
ProteomicsMultiomics approach to decipher pathophysiological mechanisms and therapeutic impact of methionine restriction in cystathionine β-synthase deficient homocystinuria
Background. Cystathionine β-synthase (CBS)-deficient homocystinuria (HCU) is an inherited disorder of sulfur amino acid metabolism with varying severity and organ complications, and a limited knowledge about underlying pathophysiological processes. Here we aimed at getting an in-depth insight into d...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-03 | PXD049417 | Pride
Cystathionine beta-synthase  homocystinuria  methionine restriction  metabolomics  proteomics 
ProteomicsDesmin knock-out cardiomyopathy: a heart on the verge of metabolic crisis
Background: Mutations of the desmin gene cause familial and sporadic cardiomyopathies and myopathies. Previous studies showed that both the lack of desmin and expression of mutated desmin negatively impact on number, structure and function mitochondria implying a metabolic dysfunction as disease pro...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-21 | PXD030938 | Pride
Metabolism Fatty acid Desmin Mitochondria Glucose Desminopathy Desmin knock-out Creatine kinase Cardiomyopathy Amino acid 
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