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ProteomicsAnalysis of reduction capability of GrxS12 on SufB and its cysteine residues
To elucidate the reduction of GrxS12 on SufB, an in vitro reducing system was utilized. The mass spectrometry analysis of the GrxS12-reduced SufB samples identified and quantified a large number of SufB peptides containing a total of eight Cys residues. The Cys-containing peptides of SufB exhibited ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-01-16 | PXD058901 | Pride
Grxs12 Sufb Reduction of cysteine residue 
TranscriptomicsThe global expression profile of Bacillus subtilis to the toxic carbonyls methylglyoxal (MG) and formaldehyde (FA)
Abstract of associated menuscript; Quinones and alpha,beta-unsaturated carbonyls are naturally occurring electrophiles that target cysteine residues via thiol-(S)-alkylation. We analyzed the global expression profile of Bacillus subtilis to the toxic carbonyls methylglyoxal (MG) and formaldehyde (FA...
ORGANISM(S): Bacillus subtilis 
2010-05-15 | E-GEOD-13925 | biostudies-arrayexpress
ProteomicsCombining redox proteomics with proximity labeling to monitor localized cysteine oxidation
Reactive oxygen species (ROS) can modulate protein function through cysteine oxidation. Identifying targets of ROS can provide insight into uncharacterized ROS-regulated pathways. Several redox-proteomic workflows, such as OxICAT, exist to identify sites of cysteine oxidation. However, determining R...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-05-21 | PXD034118 | Pride
Cysteine oxidation Apex Reactive oxygen species Oxicat Turboid Proximity labeling 
UnknownChloroplast translation factor EF-Tu of Arabidopsis thaliana can be inactivated via oxidation of a specific cysteine residue.
Not available
S-EPMC10212517 | biostudies-literature
ProteomicsAcetylation of Proximal Cysteine-Lysine Pairs by Alcohol Metabolism
Alcohol consumption induces hepatocyte damage through complex processes involving oxidative stress and disrupted metabolism. Combined, these factors alter proteomic and epigenetic marks providing a critical opportunity to identify therapeutic targets. Indeed, alcohol-induced protein acetylation is a...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-17 | PXD054686 | Pride
Alcohol-associated liver disease Protein modeling Mass spectrometry Cysteine proteomics Redox Acetylation 
ProteomicsAssessment of biarsenical dye-reactive cysteine residues of human metallothionein MT1E
Metallothioneis are low-molecular weight proteins engaged in zinc and copper ion homeostasis and redox potential regulation of the cell. Their clinical importance lies in their role in cancer resistance to cisplatin related drugs, which is related to their capability of binding sole toxic metal ions...
ORGANISM(S): Homo sapiens (Human) 
2024-12-16 | PXD048982 | Pride
Alkylation Mse protein in vitro modification analysis Biarsenical dye Human Metallothionein Crash Lc-mse 
UnknownGeneration of therapeutic immunoconjugates via Residue-Specific Conjugation Technology (RESPECT) utilizing a native cysteine in the light chain framework of Oryctolagus cuniculus.
Not available
S-EPMC5499757 | biostudies-literature
ProteomicsD-Cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1
Selective targeting of cancer cells is a major challenge for cancer therapy. Many cancer cells overexpress the cystine/glutamate antiporter xCT/CD98, a transport system that imports L-cystine to strengthen antioxidant defenses, thereby promoting tumour survival and progression. We have exploited thi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-01 | PXD063479 | Pride
Iron-sulfur cluster Iron-sulfur protein biogenesis Iron homeostasis. Cancer Amino acid 
UnknownKinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease.
Not available
S-EPMC5290728 | biostudies-literature
TranscriptomicsA kidney-protective mechanism via cellular oxidative stress reduction induced by CD5L protein [UUO_scRNAseq]
Chronic kidney disease (CKD) encompasses multiple pathogenic mechanisms manifested by inflammation, fibrosis, oxidative stress and cell death. We previously showed that circulating protein CD5L (or AIM) ameliorates acute kidney injury, so we explored its effect in a mouse model of unilateral uretera...
ORGANISM(S): Mus musculus 
2026-05-26 | GSE324542 | GEO
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