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MetabolomicsPhotosynthetic bioenergetic-redox restoration rejuvenates the aged muscle regenerative niche

Aging impairs muscle regeneration, but the key constraint remains unclear. Aged injured muscle fails to restore mitochondrial respiration, membrane potential, ATP/NADPH balance and redox control, forming a bioenergetic-redox bottleneck. To target this, we engineered CM-NTU-Ce, a C2C12 membrane-co...

2026-08-13 | MTBLS15312 | MetaboLights
ProteomicsQuantitative proteomics after spinal cord injury in a regenerative and a non-regenerative stage in Xenopus laevis
The capacity to regenerate the spinal cord after an injury is a coveted trait that only a limited group of non-mammalian organisms can achieve. In Xenopus laevis, this capacity is only present during larval or tadpole stages, but is absent during postmetamorphic frog stages. This provides an excelle...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2018-01-25 | PXD006993 | Pride
Spinal cord injury Regenerative and a non-regenerative stage Quantitative proteomics Xenopus laevis 
TranscriptomicsQuantification of regenerative potential in primary human mammary epithelial cells
We present an organoid regeneration assay in which freshly dissociated human mammary epithelial cells from healthy donors are grown in adherent/rigid or floating/compliant collagen I gels. In both conditions, luminal progenitors (CD49f+EpCAM+) form spheres, whereas basal cells (CD49fhiEpCAM-) genera...
ORGANISM(S): Homo sapiens 
2015-07-02 | E-GEOD-64248 | biostudies-arrayexpress
TranscriptomicsIntrinsic regenerative potential of murine cochlear supporting cells
P3 Math1-nGFP mouse cochlear sensory epithelia, consisting of greater and lesser epithelial ridges (GER & LER) including the organ of Corti with nGFP-positive hair cells, were dissected, dissociated into single cells, and labeled with propidium iodide and three CD marker antibodies. The cell suspen...
ORGANISM(S): Mus musculus 
2014-10-22 | E-GEOD-62582 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human hepatic cells derived from foreskin fibroblast cell line and from embryonic stem cells.
Reprogrammed somatic cells offer a valuable source of pluripotent cells that have the potential to differentiate into many cells types and provide a new tool for regenerative medicine. In the present study we differentiated induced pluripotent stem cells (iPS cells) into hepatic cells. We first show...
ORGANISM(S): Homo sapiens 
2009-08-07 | E-GEOD-14897 | biostudies-arrayexpress
ProteomicsComparative Proteomic Analysis of Dental-Origin Stem Cells: Insights into Regenerative Potential
Teeth are a significant source of stem cells and have clinical importance for regenerative medicine. A human tooth harbors different kinds of stem cells in the dental pulp (DPSC) or the periodontal ligament (PDLSC). Also exfoliated teeth in childhood contain a special type of stem cells in their pul...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD058096 | Pride
Proteome Pdlsc Dpsc Secretome Shed 
TranscriptomicsGeneration of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine
Human induced pluripotent stem (iPS) cells have the potential to establish a new field of promising regenerative medicine. Therefore, the safety and the efficiency of iPS-derived cells must be tested rigorously using appropriate animal models before human trials can commence. Here, we report the est...
ORGANISM(S): Oryctolagus cuniculus 
2010-07-28 | E-GEOD-23190 | biostudies-arrayexpress
GenomicsDifferentiated prostate luminal cells acquire enhanced regenerative potential after androgen ablation
Differentiated prostate luminal cells acquire enhanced regenerative potential after androgen ablation
PRJNA625051 | ENA
ProteomicsProfiling extra cellular matrix core proteome of human fetal nucleus pulposus in search for regenerative targets
Intervertebral disc degeneration is accompanied by a loss of Extra-cellular matrix (ECM) content due to an imbalance in anabolic and catabolic pathways. Identifying ECM proteins with anabolic and/or regenerative potential could be the key to developing regenerative therapies. Since human fetal discs...
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD021431 | Pride
Np Esi-lc-ms/ms Adult Human Fetus Regenerative potential. Ivd Degenerated discs 
GenomicsInterspecies comparison reveals Hmga1 as a key determinator of cardiac regenerative potential
Interspecies comparison reveals Hmga1 as a key determinator of cardiac regenerative potential
PRJNA691756 | ENA
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