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TranscriptomicsActin Cytoskeleton Integrates Auxin and Brassinosteroid Signaling in Plants.
We describe a new mutant allele of the ACTIN2 gene with enhanced actin dynamics, displaying a broad array of twisting and bending phenotypes that resemble BR-treated plants. Moreover, auxin transcriptional regulation is enhanced on the mutant background, supporting the idea that shaping actin filame...
ORGANISM(S): Arabidopsis thaliana 
2012-11-21 | E-GEOD-27077 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis of DFAT cells after the treatment with Y-27632 and the transfection of Mkl1 siRNA
Cellular differentiation is regulated through activation and repression of defined transcription factors. A hallmark of differentiation is a pronounced change in cell shape, which is determined by dynamics of the actin cytoskeleton. In de-differentiated fat (DFAT) cells and 3T3-L1 cells, we showed t...
ORGANISM(S): Mus musculus 
2014-03-28 | E-GEOD-52334 | biostudies-arrayexpress
ProteomicsN-terminal processing of beta and gamma actin in human platelets
Actin is one of the most essential and abundant intracellular proteins, playing an essential physiological role as the major constituent of the actin cytoskeleton. Two cytoplasmic actins, beta- and gamma-actin, are encoded by different genes, but their amino acid sequences differ only by four conser...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032086 | Pride
Actin Human Platelet 
ProteomicsKLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium
The shear stress-induced transcription factor Krüppel-like factor 2 (KLF2) confers anti-inflammatory properties to endothelial cells through inhibition of activator protein 1, presumably by interfering with MAPK cascades. To gain insight into the regulation of these cascades by KLF2, we used antibo...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-19412 | biostudies-arrayexpress
ProteomicsN-terminal processing of beta and gamma actin in MEF cells
Actin is one of the most essential and abundant intracellular proteins, playing an essential physiological role as the major constituent of the actin cytoskeleton. Two cytoplasmic actins, beta- and gamma-actin, are encoded by different genes, but their amino acid sequences differ only by four conser...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD032139 | Pride
Mouse Mef Actin 
ProteomicsN-terminal processing of beta and gamma actin in HAP1 cells
Actin is one of the most essential and abundant intracellular proteins, playing an essential physiological role as the major constituent of the actin cytoskeleton. Two cytoplasmic actins, beta- and gamma-actin, are encoded by different genes, but their amino acid sequences differ only by four conser...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031481 | Pride
Actin Human Hap1 
Proteomics3’,5’-cAMP affects actin cytoskeleton dynamics by direct binding to actin.
Cyclic adenosine monophosphate (3’,5’-cAMP) is a well-characterized and evolutionary conserved second messenger. In contrast to the animal cells, however, the role of 3’,5’-cAMP in plants remains enigmatic. With the exception of cyclic nucleotide-gated ion channels, no plant 3’,5’-cAMP interactors h...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-06-02 | PXD019537 | Pride
Camp Actin Cytoskeleton Arabidopsis thaliana Signalling 
TranscriptomicsForm and function of actin impacts actin health and aging.RNAseq
The actin cytoskeleton is a highly conserved structural network that supports diverse cellular processes, but its contribution to organismal aging is not well understood. This project investigates how genetic and pharmacological perturbations of actin and actin-binding proteins influence global gene...
ORGANISM(S): Caenorhabditis elegans 
2026-05-11 | E-MTAB-16193 | biostudies-arrayexpress
TranscriptomicsLarge-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin health and lifespan
The actin cytoskeleton is a three-dimensional scaffold of proteins that is a regulatory, energy-consuming material with dynamic properties shaping the structure and function of the cell. The proper function of actin is required for many cellular pathways, including cell division, autophagy, chaperon...
ORGANISM(S): Caenorhabditis elegans 
2023-06-01 | E-MTAB-11786 | biostudies-arrayexpress
TranscriptomicsLarge-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin health and lifespan
The actin cytoskeleton is a three-dimensional scaffold of proteins that is a regulatory, energy-consuming material with dynamic properties shaping the structure and function of the cell. The proper function of actin is required for many cellular pathways, including cell division, autophagy, chaperon...
ORGANISM(S): Caenorhabditis elegans 
2023-06-01 | E-MTAB-12289 | biostudies-arrayexpress
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