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TranscriptomicsTranscription profiling of human bronchial epithelial cells to low doses of cigarette smoke condensate - chronic exposure
BEAS-2B cells have been treated with low doses (20 ug/ml) of CSC for 4 months. As negative control BEAS-2B cells were treated with DMSO (the CSC solvent). Non-treated cells were cultivated in parallel. Experiment Overall Design: After each month total RNA was extracted from three replicates of CSC, ...
ORGANISM(S): Homo sapiens 
2009-08-09 | E-GEOD-14383 | biostudies-arrayexpress
TranscriptomicsExpression profiling of the host and the Ovine Herpesvirus 2 pathogen during malignant catarrhal fever of cattle
This SuperSeries is composed of the following subset Series: GSE13852: Expression profiling of Bos taurus lymph nodes upon infection with Ovine Herpesvirus 2 GSE13853: Expression profiling of Ovine Herpesvirus 2-infected lymph nodes from Bos taurus Refer to individual Series
ORGANISM(S): Bos taurus 
2010-05-15 | E-GEOD-13854 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of bladder tissue of patients with interstitial cystitis
Interstitial cystitis (IC) is a progressive chronic bladder disease with an increasing incidence. Today, IC is diagnosed by subjective symptoms in combination with cystoscopic and histologic evidence. The ultimate goal is the development of a diagnostic assay for IC on a molecular level. A comparati...
ORGANISM(S): Homo sapiens 
2009-05-14 | E-GEOD-11783 | biostudies-arrayexpress
TranscriptomicsDemethylation profiling of human lung cancer cell lines
The goal of this study is to identify those genes that are commonly silenced by DNA-methylation in lung cancer cell lines. Experiment Overall Design: Ten lung cancer cell lines (Calu 1, Hotz, U1752, Calu 6, ZL25, Calu3, SW2, A549, H125, and H 460) were analyzed before and after the treatment with 5-...
ORGANISM(S): Homo sapiens 
2009-08-09 | E-GEOD-14315 | biostudies-arrayexpress
TranscriptomicsTargeting the Phosphoinositide 3-Kinase p110-alpha Isoform Impairs Cell Proliferation, Survival and Tumor Growth in Small Cell Lung Cancer
Purpose: The phosphoinositide 3-kinase (PI3K) pathway is fundamental for cell proliferation and survival and is frequently altered and activated in neoplasia, including carcinomas of the lung. In this study we investigated the potential of targeting the catalytic class IA PI3K isoforms in small cell...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-40564 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Ovine Herpesvirus 2-infected lymph nodes from Bos taurus
We hypothesized that the gene expression pattern of OvHV-2 may be important to understand the pathogenesis of malignant catarrhal fever (MCF). Therefore, RNA was extracted from lymph nodes of animals with MCF and healthy controls to be analyzed by a custom-made microarray. Two regions on the viral g...
ORGANISM(S): Bos taurus 
2010-05-15 | E-GEOD-13853 | biostudies-arrayexpress
TranscriptomicsAblation of Dicer from murine Schwann cells increases their proliferation while blocking myelination
The myelin sheaths that surround the thick axons of the peripheral nervous system are produced by the highly specialized Schwann cells. Differentiation of Schwann cells and myelination occur in discrete steps. Each of these requires coordinated expression of specific proteins in a precise sequence, ...
ORGANISM(S): Mus musculus 
2010-12-01 | E-GEOD-22023 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cortical collecting duct/connecting nephron tissue from mice treated with aldosterone, canrenoate vs. controls to identify gene products regulated by aldosterone in target cells
The mineralocorticoid hormone aldosterone controls sodium reabsorption and blood pressure largely by regulating the cell-surface expression and function of the epithelial sodium channel ENaC in target kidney tubules. Part of the stimulatory effect of aldosterone on ENaC is mediated by the induct...
ORGANISM(S): Mus musculus 
2007-03-07 | E-TABM-229 | biostudies-arrayexpress
TranscriptomicsGenome-wide transcription analysis of Escherichia coli in response to extremely low-frequency magnetic fields
The widespread use of electricity raises the question of whether or not 50 Hz (power line frequency in Europe) magnetic fields (MFs) affect organisms. We investigated the transcription of Escherichia coli K-12 MG1655 in response to extremely low-frequency (ELF) MFs. Fields generated by three signal ...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2012-01-28 | E-GEOD-35371 | biostudies-arrayexpress
TranscriptomicsIntegrative transcriptome profiling of cognitive aging and its preservation through Ser/Thr protein phosphatase regulation
Environmental enrichment has been reported to delay or restore age-related cognitive deficits, however, a mechanism to account for the cause and progression of normal cognitive decline and its preservation by environmental enrichment is lacking. Using genome-wide SAGE-Seq, we provide a global assess...
ORGANISM(S): Mus musculus 
2015-06-24 | E-GEOD-43718 | biostudies-arrayexpress
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