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no omics definedTranscription profiling of mononucleated cells cultured in EndoCult and reference media
Impact of the culture system on functional differentiation of Mononucleated cells
ORGANISM(S): Homo sapiens 
2006-12-01 | E-MEXP-723 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesenchymal stromal cells to reveal senescence associated gene expression changes
Transcription profiling of human mesenchymal cells (MSCs) after ex vivo expansion under culture conditions supporting extensive cell proliferation. Highly efficient cell expansion within short time (~40 days) and comparison of gene expression profiles from MSCs after primary seeding, defined as earl...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-MEXP-1997 | biostudies-arrayexpress
ProteomicsFasting reverses drug-resistance in hepatocellular carcinoma through p53-dependent metabolic synergism
Cancer cells voraciously consume nutrients to support their growth, exposing a metabolic vulnerability that can be therapeutically exploited. Here we show in hepatocellular carcinoma (HCC) cells, xenografts, and in patient-derived HCC organoids that fasting can synergistically sensitise resistant HC...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-16 | PXD022723 | Pride
Xenografts Starvation Hcc Sorafenib Tp53 Hepg2 
TranscriptomicsHuman bone and marrow niche formation by mesenchymal progenitors in vivo is predefined by an organotypic epigenetic signature
In this study, we have analyzed DNA methylation characteristics of human mesenchymal stem and progenitor cells (MSPCs) form different tissue sources including bone marrow (BM), white adipose tissue (WAT ), umbilical cord (UC) as well as dermal fibroblasts by using the HumanMethylation450K array. Cel...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-41933 | biostudies-arrayexpress
ProteomicsAdipocyte p53 coordinates the adipose tissue immune cell landscape upon intermittent fasting
In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that limits the effectiveness of weight loss interventions. Yet, its fasting regimen-dependent regulation is unknown. Here, we show that cyclic intermittent fasting (IF) exacerbates the lipid-associated macrophage (...
ORGANISM(S): Homo sapiens (Human) 
2024-01-16 | PXD041351 | Pride
Proteomics Fasting Adipose tissue P53 
ProteomicsProximity-biotinylation (BioID) to dissect cytoplasmic p53 signaling networks under nutrient stress
p53 signaling is a major response mechanism to cellular stresses through cytoplasmic or nuclear action. While p53 protein levels have been shown to increase upon nutrient stresses such as starvation, the exact signaling cascade in this context remains elusive. Here, we use proximity biotinylation (B...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD027734 | Pride
Nutrient stress Starvation P53 signaling Bioid Interactome 
UnknownTargeting human CALR mutated MPN progenitors with a neoepitope-directed monoclonal antibody
Not available
S-SCDT-EMBOR-2021-52904V1 | biostudies-other
TranscriptomicsFunctional and transcriptional heterogeneity of human hemopoietic lympho-myeloid progenitors
Cord blood (CB) samples from normal donors were obtained with informed consent. Fresh CB samples were processed within 18-34h after collection. Mononuclear cells were isolated and CD34+ fraction was separated. CB CD34+ enriched fraction was lineage depleted by staining with purified anti-human CD2, ...
ORGANISM(S): Homo sapiens 
2017-10-03 | E-MTAB-5456 | biostudies-arrayexpress
TranscriptomicsEpigenetic and in vivo comparison of diverse mesenchymal stromal cell sources reveals an endochonrdal signature for human hematopoietic niche formation
Despite similarities in morphology, phenotype and in vitro behavior, Mesenchymal Stromal Cells (MSC) form various tissue sources show striking differences in their in vivo potential to form bone, cartilage and hematopoietic support tissue. Comparing four commonly use MSC sources (bone marrow (BM), ...
ORGANISM(S): Homo sapiens 
2014-04-30 | E-GEOD-57151 | biostudies-arrayexpress
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