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ProteomicsAUF1 recognizes 8-oxo-guanosine embedded in DNA and stimulates APE1 endoribonuclease activity
The presence of rNMPs embedded in DNA represents a frequent genomic event able to destabilize the DNA backbone and to alter DNA replication and transcription. Usually, rNMPs are excised by RNase H2 and fully repaired by other enzymes belonging to the ribonucleotide excision repair pathway. The exist...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD027252 | Pride
Ape1 Dna-binding protein 
ProteomicsA differential proteomic approach highlighted differences induced by plant growth promoting bacteria in Solanum lycopersicum treated with Kocuria rhizophila and Streptomyces violaceoruber
During the last decades, the use of plant growth promoting bacteria (PGPB) has been found to increase crop yield and quality and to confer abiotic and biotic stress tolerance. However, until now the PGPB mechanism to enhance plant performances is not clearly defined. Recently, our findings demonstra...
ORGANISM(S): Solanum lycopersicum 
2024-05-02 | PXD038137 | Pride
Proteomics Plant growth promoting bacteria Tomato 
ProteomicsTMT-based quantitative proteomic analysis of extracellular vesicles (EVs) released from brown/white adipose tissue following cold exposureTMT-based quantitative proteomic analysis of extracellular vesicles (EVs) released from brown/white adipose tissue following cold exposure
The proteome cargo of extracellular vesicles released from brown adipose tissue (BAT) and from white adipose tissue (WAT) of mice subjected to cold exposure (4°C) was analysed by a TMT-based quantitative proteomic procedure in order to obtain new information on the processes of thermogenesis.
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD026080 | Pride
Tmt Lc-ms Bat/wat Evs 
ProteomicsThe small ORF trpM stimulates growth and actinorhodin production in Streptomyces coelicolor
In actinomycetes, antibiotic production is often associated with a morpho-physiological differentiation program that is regulated by complex molecular and metabolic networks. Many aspects of these regulatory circuits have been already elucidated and many others still deserve further investigations...
ORGANISM(S): Streptomyces coelicolor 
2020-03-27 | PXD015937 | Pride
Streptomyces coelicolor Primary and secondary metabolism Calcium-dependent antibiotic (cda) Actinorhodin production Cytosol aminopeptidase Small orf 
ProteomicsProteomic analysis of Streptomyces coelicolor vesicles
Streptomyces coelicolor is a model organism for the study of Streptomyces, a genus of Gram-positive bacteria that undergoes a complex life cycle and produces an enormous repertoire of bioactive metabolites and extracellular enzymes. This study investigated the production and characterization of memb...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2021-11-02 | PXD024085 | Pride
Lc-msms analysis Proteomics Streptomyces coelicolor vesicles 
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