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MetabolomicsMulti-omics reveals effects of several rumen bacteria on reproductive performance of sheep

Background: Mounting evidence indicates that the rumen microbiota plays a crucial role in the reproductive health of sheep. However, the potential beneficial effects of rumen microbiota on lambing performance in sheep across different stages of the reproductive cycle and the precise mechanisms un...

2026-03-03 | MTBLS13963 | MetaboLights
MetabolomicsPhenomic and multiomic characterisation of microsatellite-stable colorectal cancer reveals novel biology and targets of vulnerability

Integrating data from approximately 2,000 tumour samples, corresponding to ~4,500 platform-specific multiomic sample profiles, and 195,246 single cells/nuclei from diverse in-house and publicly available datasets, single-to-integrated multiomic and clinical phenome data fusion analysis uncovers t...

2026-09-15 | MTBLS15127 | MetaboLights
TranscriptomicsTranscription profiling of Drosophila Hr39 mutant females reveals the sf1-related nuclear hormone receptor hr39 regulates Drosophila female reproductive tract development and function
The vertebrate nuclear hormone receptor steroidogenic factor 1 (SF1; NR5A1) controls reproductive development and regulates the transcription of steroid-modifying cytochrome P450 genes. We find that the SF1-related Drosophila nuclear hormone receptor HR39 is also essential for sexual development. In...
ORGANISM(S): Drosophila melanogaster 
2008-06-11 | E-GEOD-10264 | biostudies-arrayexpress
ProteomicsEvolutionary quantitative proteomics of reproductive interactions in Drosophila
We present data using a novel method to simultaneously identify and quantify transferred male seminal proteins and the female reproductive proteome using multiplexed Tandem-Mass-Tag (TMT) isobaric labelling of the lower female reproductive tracts dissected from virgin- or recently mated- females of ...
ORGANISM(S): Drosophila novamexicana Drosophila americana Drosophila virilis 
2023-10-24 | PXD031638 | Pride
Drosophila novamexicana Drosophila americana Tmt Sperm Seminal fluid proteins Female reproductive tract Reproductive isolation Postmating prezygotic isolation Drosophila virilis 
ProteomicsComparison of post-mating responses in the female reproductive tract among Drosophila species
Fertility depends on the coordination of complex interactions between male and female reproductive proteins inside the female reproductive tract (FRT). These interactions mediate a suite of changes in female behavior, morphology, and physiology after mating, yet little is known about how the molecul...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-06-25 | PXD017730 | Pride
Female reproductive tract Lc-m Post-mating responses Drosophila melanogaster 
TranscriptomicsTargeted disruption of BMAL1 in the peripheral reproductive axis results in infertility in female mice
The product of the Bmal1 locus is an essential component of the circadian clock that plays important roles in various aspects of reproductive biology,and when disrupted results in infertility. In an effort to establish the identity of the tissue specific clock that is responsible for this infertilit...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-48758 | biostudies-arrayexpress
ProteomicsEvolution of the reproductive interactome and the origins of postmating–prezygotic reproductive divergence
Reproductive proteins evolve rapidly, which is predicted to cause postmating-prezygotic (PMPZ) reproductive isolation between divergent populations. While most previous studies have focused on protein sequence divergence as a likely driver of PMPZ incompatibilities, reproductive proteomes may also d...
ORGANISM(S): Drosophila mojavensis mojavensis Drosophila arizonae 
2026-04-02 | PXD065290 | Pride
ProteomicsThe life history of Drosophila sperm depends on molecular continuity between male and female reproductive tracts
Interactions between sperm and the female reproductive tract (FRT) are critical to fertility, but knowledge of the molecular mechanisms by which the FRT interacts with sperm and influences sperm fate remains limited. Here, we used whole-cell quantitative proteomics to track the protein composition o...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-03-14 | PXD027807 | Pride
Lc-msms Female reproductive tract Fertility Sperm Drosophila melanogaster 
ProteomicsQuantitative proteomics reveals rapid divergence in the postmating response of female reproductive tracts among sibling species
Fertility depends, in part, on interactions between male and female reproductive proteins inside the female reproductive tract (FRT) that mediate postmating changes in female behavior, morphology, and physiology. Coevolution between interacting proteins within species may drive reproductive incompat...
ORGANISM(S): Drosophila simulans Drosophila mauritiana 
2020-06-25 | PXD017708 | Pride
Drosophila simulans Lc-msms Female reproductive tract Tmt Drosophila mauritiana 
ProteomicsThe life history of Drosophila sperm depends on molecular continuity between male and female reproductive tracts: heavy-male isotopic labeling to identify female-derived sperm proteins
Interactions between sperm and the female reproductive tract (FRT) are critical to fertility, but knowledge of the molecular mechanisms by which the FRT interacts with sperm and influences sperm fate remains limited. Here, we used sex-specific isotopic labeling to identify female-derived proteins th...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-03-11 | PXD027802 | Pride
Lc-msms Female reproductive tract Fertility Sperm Silac Drosophila melanogaster 
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