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MetabolomicsImmunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure
Respiratory failure and mortality from COVID-19 result from virus- and inflammation-induced lung tissue damage. The intestinal microbiome and associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe COVID-19 remains uncl...
2023-05-02 | MTBLS5288 | MetaboLights
MetabolomicsTraining-induced bioenergetic improvement in human skeletal muscle is associated with non-stoichiometric changes in the mitochondrial proteome without reorganisation of respiratory chain content
Not available
ORGANISM(S): Homo sapiens 
ST001907 | MetabolomicsWorkbench
MetabolomicsAirway metabolic profiling during Streptococcus pneumoniae infection identifies branched chain amino acids as signatures of upper airway colonisation

Streptococcus pneumoniae is a leading cause of community-acquired pneumonia and bacteraemia and is capable of remarkable phenotypic plasticity, responding rapidly to environmental change. Pneumococcus is a nasopharyngeal commensal, but is responsible for severe, acute infections followin...

2023-08-08 | MTBLS4591 | MetaboLights
MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
TranscriptomicsTranscription profiling of yeast rho0 cells (complete deletion of the mitochondrial genome), in cells with either a single defective enzyme or several, vs cells after prolonged treatment with the bc1 inhibitors myxothiazol or antimycin to analyse respiratory defects
The mitochondrial respiratory chain is composed of lipoprotein complexes imbedded in the inner mitochondrial membrane. This chain of enzymes transfers electrons from NADH and FADH2, provided from divers metabolic pathways, to oxygen. It couples the transfer of electrons to the translocation of proto...
ORGANISM(S): Saccharomyces cerevisiae 
2009-02-20 | E-MEXP-585 | biostudies-arrayexpress
ProteomicsSubcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of compromised mitochondrial DNA repair.
The mitochondrial mutator mouse is a well-established model of premature aging in which a progeroid phenotype is driven by the accumulation of somatic mtDNA mutations. Despite evidence of bioenergetic disruption within the cardiac mitochondria, there is little information about the underlying change...
ORGANISM(S): Mus Musculus (mouse) 
2021-01-08 | PXD017000 | JPOST Repository
TranscriptomicsTranscription profiling of mouse age-related hearing loss cochlea in DBA/2J
Age-related hearing loss (AHL) is the progressive loss of auditory function with aging. The DBA/2J (DBA) mice have been used as a model of AHL and undergoes progressive, age-related hearing loss by 12 weeks of age. Here we analyzed cochlear gene expression of 7-week-old and 36-week-old DBA mice usin...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6045 | biostudies-arrayexpress
ProteomicsMycobacteria tolerate carbon monoxide by remodelling their respiratory chain
Carbon monoxide (CO) is a gas infamous for its acute toxicity. The toxicity of CO predominately stems from its tendency to form carbonyl complexes with transition metals, thus inhibiting the heme-prosthetic groups of proteins, including the terminal oxidases of the respiratory chain. While CO has be...
ORGANISM(S): Mycobacterium sp. GN-10803 
2021-04-30 | PXD018382 | Pride
Mycobacteria Respiratory chain Carbon monoxide 
ProteomicsPreserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes
The mammalian respiratory chain complexes I, III2 and IV (CI, CIII2 and CIV) are critical for cellular bioenergetics and form a stable assembly, the respirasome (CI-CIII2-CIV), that is biochemically and structurally well documented. The role of the respirasome in bioenergetics and regulation of meta...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-19 | PXD023846 | Pride
Tmt Supercomplex Oxphos Mitochondria Complexome profiling 
ProteomicsLoss of mitochondrial complex II causes severe respiratory chain dysfunction
Mitochondrial complex II (succinate dehydrogenase, SDH) links the tricarboxylic acid cycle to the respiratory chain. To investigate how disruption of complex II affects mitochondrial respiratory organization, we generated cell lines lacking either SDHA or SDHB and systematically characterized the ac...
ORGANISM(S): Homo sapiens (Human) 
2026-07-03 | PXD076790 | Pride
Respiratory chain Complex ii 
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