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TranscriptomicsTranscription profiling of rat nasal respiratory and olfactory epithelium
The nasal epithelium is an important target site for chemically-induced toxicity and carcinogenicity. Human epidemiological investigations and experimental laboratory animal studies show that the nasal olfactory epithelium is selectively damaged by inhalation exposure to several chemicals, includin...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5019 | biostudies-arrayexpress
TranscriptomicsNasal epithelium gene expression profiling in child respiratory allergic disease
Background: In asthma, airway epithelium remodeling can already be detected during childhood, and epithelial cells are more susceptible to virus and oxidative stress. Their exact role in natural history and severity of children allergic respiratory disease remains however surprisingly unexplored. A...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-19187 | biostudies-arrayexpress
TranscriptomicsGene expression from bronchial and nasal epithelial cell samples of healthy current and never smokers.
mRNA expression was assayed from bronchial epithelial cells collected via bronchoscopy and nasal epithelial cells collected by brushing the inferior turbinate from healthy current and never smoker volunteers in order to determine the relationship between smoking-related gene expression changes in b...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-16008 | biostudies-arrayexpress
TranscriptomicsDistinct epithelial gene expression phenotypes in childhood respiratory allergy
This SuperSeries is composed of the following subset Series: GSE19182: Gene expression profiling of differentiated HNECs stimulated by IL4, IL13, IFNalpha, IFNbeta, IFNgamma and controls GSE19187: Nasal epithelium gene expression profiling in child respiratory allergic disease Refer to individual Se...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-19190 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of the response of Rattus norvegicus nasal epithelial cells to treatment with various doses of formaldehyde
Formaldehyde, an important industrial chemical, is used for multiple commercial purposes throughout the industrialized world. This simple, one carbon aldehyde is a natural metabolite formed in cells throughput the body. However, it is also a rodent nasal carcinogen, when inhaled by rats every day ...
ORGANISM(S): Rattus norvegicus 
2007-10-25 | E-GEOD-7002 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat nasal respiratory epithelium laser capture microdissected after exposure to hydrogen sulfide
Hydrogen sulfide (H2S) is a naturally occurring gas that is also associated with several industries. The potential for widespread human inhalation exposure to this toxic gas is recognized as a public health concern. The nasal epithelium is particularly susceptible to H2S-induced pathology. Injury...
ORGANISM(S): Rattus rattus 
2009-10-18 | E-GEOD-5349 | biostudies-arrayexpress
TranscriptomicsFormaldehyde-induced changes in microRNA signaling [Affymetrix]
In addition to gaining knowledge on in vivo miRNA responses to formaldehyde, we set out to relate these miRNA responses to transcriptional profiles modified by formaldehyde. Rats were exposed by inhalation to either 0 or 2 ppm formaldehyde (6 hours/day) for 28 days. Genome-wide transcriptional profi...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-42394 | biostudies-arrayexpress
Transcriptomics3-D nasal cultures: Systems toxicological assessment of a candidate modified-risk tobacco product (nasal epithelial cells-microRNA dataset).
In vitro toxicology approaches have evolved, from a focus on the molecular changes within a cell to understanding of toxicity-related mechanisms that simulate the in vivo environment. The recent development of three dimensional (3-D) organotypic nasal epithelial culture models offer a physiologicall...
ORGANISM(S): Homo sapiens 
2018-04-01 | E-MTAB-6613 | biostudies-arrayexpress
TranscriptomicsEffect of cessation after initial exposure to cigarette smoke
Although smoking cessation shows clear cardiovascular risk benefits, lung-related disease risk remains higher in former smokers than in never smokers. To better understand the factors involved in this phenomenon, ApoE-/- mice were exposed to mainstream cigarette smoke (CS) or a smoking cessation-mim...
ORGANISM(S): Mus musculus 
2013-10-19 | E-MTAB-1390 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human buccal and nasal epithelium of current and never smokers
Smoking is the leading cause of lung cancer death, although only a small percentage of smokers develop the disease. Cigarette smoke exposure is known to cause a field of injury in cells throughout the respiratory tract, and while these airway epithelial cells are morphologically normal, they can und...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-8987 | biostudies-arrayexpress
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