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MetabolomicsRat Retinal Detachment Metabolomics Timecourse
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ORGANISM(S): Rattus norvegicus 
ST000832 | MetabolomicsWorkbench
TranscriptomicsTranscriptomic analysis of human retinal detachment (RD) reveals both inflammation and photoreceptor death
We have used surgical specimens to perform a differential analysis of the transcriptome of human retinal tissues following detachment. Data analysis reveals major involvement of the immune response in the disease and interindividual variation was monitored to unravel a second crucial aspect of the p...
ORGANISM(S): Homo sapiens 
2012-03-06 | E-GEOD-28133 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse with retinal detachment and accelerated re-attachment
Retinal detachment is a major cause of blindness due to penetrating trauma and ocular inflammation, and is often observed in many patients following cataract extraction surgery. When the retinal photoreceptors detach from their epithelium, stress signals and apoptotic pathways are initiated that wi...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5766 | biostudies-arrayexpress
ProteomicsComparative Proteomic Analysis of Human Vitreous in Rhegmatogenous Retinal Detachment and Diabetic Retinopathy
The vitreous humor can provide important information about physiological and pathophysiological processes within the eye, particularly concerning the retina. Despite the widespread prevalence of various vitreoretinal diseases, that can ultimately lead to blindness, there is not a clear understanding...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD050611 | Pride
Diabetic retinopathy Human vitreous humor Rhegmatogenous retinal detachment 
ProteomicsALTERED PATTERN OF PROTEOLYSIS OF EXTRACELLULAR PROTEINS IN RHEGMATOGENOUS RETINAL DETACHMENT BY MINING OF TRYPTIC AND N-TERMINI DATASETS FROM VITREOUS HUMOR PROTEOME
Retinal detachment is a severe eye condition characterized by the detachment of the neurosensory retina from the retinal pigment epithelium and caused by retinal tears. Pars plana vitrectomy is the elective surgical procedure during which vitreous humor, a fluid which shapes the eye globe and suppor...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD057155 | Pride
Eye Vitreous humor Uhplc-ms Ocular fluids Dda 
ProteomicsDual-function thermogelling polymers as effective endotamponade for retinal detachment repair and reassembly of vitreous-like body in-situ
Endo-tamponade agents are crucial surgical adjuncts for vitreo-retinal surgery. Current clinical agents provide internal tamponade through buoyancy forces requiring the need for prolonged facing down post-operative positioning. Other disadvantages include temporary loss of vision, raised intra-ocula...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2019-09-13 | PXD009525 | Pride
Eye Vitreous Thermogelling polymer Retinal detachment repair Rabbit 
ProteomicsProtein composition of the subretinal fluid suggest selective diffusion of vitreous proteins in retinal detachment
Purpose: To study the proteome of the subretinal fluid (SRF) from rhegmatogenous retinal detachment (RRD) in search for novel markers for improved diagnosis and prognosis of RRD. Methods: Human undiluted SRF obtained during vitrectomy for primary RRD using a 41G needle (n = 24) was analyzed and comp...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD019159 | Pride
Retinal detachment Subretinal fluid Vitreous humor Eye 
TranscriptomicsTranscription profiling of mouse ark adapted and light damaged BALBc (albino) retinal pigmented epithelium
Transcriptional profiles were compared between dark adapted and light damaged BALBc (albino) mouse RPE. Experiment Overall Design: BALBc mice were dark adapted for one week. To produce light damage a subset of the mice were then exposed to 6,000 lux white fluorescent light for 1.5 hours. RPEs were c...
ORGANISM(S): Mus musculus 
2008-10-26 | E-GEOD-13074 | biostudies-arrayexpress
ProteomicsMolecular pathogenesis of rhegmatogenous retinal detachment
Here, we performed molecular pathology analysis of the vitreous proteomes collected from 127 patients with RRD using SWATH-mass spectrometry. For comparison, samples of neurodegenerative vitreoretinal interface eyes (MH, Pucker) and proliferative diabetic retinopathy eyes with tractional-retinal det...
ORGANISM(S): Human 
2020-11-05 | MSV000086412 | MassIVE
ProteomicsEfficacy of steroids in the treatment of retinal detachment with choroidal detachment: Analysis by proteomics
This study aims to utilize DIA-based proteomics technology to observe the effects of preoperative steroid interventions on the vitreous proteome in retinal detachment with choroidal detachment （RRDCD） patients. Gaining a deeper understanding of the changes in vitreous humor proteins following steroi...
ORGANISM(S): Homo Sapiens 
2024-12-03 | PXD058498 |
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