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TranscriptomicsMapping and dynamics of regulatory DNA and transcription factor networks in A. thaliana
We mapped DNaseI hypersensitive sites (DHSs) and applied genomic footprinting to define in vivo transcription factor (TF) occupancy at nucleotide resolution across the A. thaliana genome in whole seedlings during heat- and light-response states. We find that trait-associated variation localizes with...
ORGANISM(S): Arabidopsis thaliana 
2013-12-15 | E-GEOD-53322 | biostudies-arrayexpress
ProteomicsGLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function
Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RAs) ameliorate mitochondrial health by increasing mitochondrial turnover in metabolically relevant tissues. Mitochondrial adaptation to metabolic stress is crucial to maintain pancreatic -cell function and prevent type 2 diabetes (T2D) progre...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-09-30 | PXD056782 | Pride
Membrane contact sites Pancreatic beta cells Mitochondrial remodelling Akaps Er-mitochondrial contacts Incretins Sphkap Compartmentalised pka signalling Glp-1r Vap-b 
ProteomicsERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning
Precise vascular patterning is critical for normal growth and development. The ERG transcription factor drives Delta like ligand 4 (DLL4)/Notch signalling and is thought to act as pivotal regulators of endothelial cell (EC) dynamics and developmental angiogenesis. However, molecular regulation of E...
ORGANISM(S): Homo sapiens (Human) 
2022-07-05 | PXD033447 | Pride
Rime Huvec Fak 
GenomicsMapping and dynamics of regulatory DNA in A. thaliana accessions
We performed DNase-seq on 7-day-old seedlings from four A. thaliana accessions: Bur-0, Tsu-0, Bay-0, Est-1 using INTACT constructs (Deal and Henikoff, Developmental Cell, 2010) driven by the UBQ10 promoter. Chromatin accessibility profiling (Dnase I-seq) of 7-day-old seedlings of A. thaliana accessi...
ORGANISM(S): Arabidopsis thaliana 
2013-12-15 | E-GEOD-53323 | biostudies-arrayexpress
UnknownFenretinide via NOXA Induction, Enhanced Activity of the BCL-2 Inhibitor Venetoclax in High BCL-2-Expressing Neuroblastoma Preclinical Models.
Not available
S-EPMC9255909 | biostudies-literature
UnknownTelomere Maintenance Mechanisms Define Clinical Outcome in High-Risk Neuroblastoma.
Not available
S-EPMC7313726 | biostudies-literature
GenomicsMapping and dynamics of regulatory DNA in A. thaliana tissues and cell types across developmental transitions
We performed DNase-seq on root tissue, root epidermal cell types, seed coat epidermal cells at two developmental stages, and open and closed flowers. Root: We performed chromatin profiling (DNase-seq) on whole root (all cell types), or root epidermal cell types (hair cell, non-hair cell). Seed coat:...
ORGANISM(S): Arabidopsis thaliana 
2013-12-15 | E-GEOD-53324 | biostudies-arrayexpress
UnknownMYC transcription activation mediated by OCT4 as a mechanism of resistance to 13-cisRA-mediated differentiation in neuroblastoma.
Not available
S-EPMC7224192 | biostudies-literature
UnknownA Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma.
Not available
S-EPMC8992729 | biostudies-literature
TranscriptomicsTranscription profiling by array of breast cancer cell lines and correlations with fibroblast growth factor receptor (FGFR) signalling and repression
Baseline gene expression profiling of breast cancer cell lines and correlations with FGFR signalling and repression
ORGANISM(S): Homo sapiens 
2011-12-01 | E-MTAB-879 | biostudies-arrayexpress
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