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TranscriptomicsDistinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
Rheb, a ras-like small GTPase conserved from human to yeast, controls Tor kinase and plays a central role in regulation of cell growth depending on extracellular conditions. Fission yeast Rheb regulates amino acid uptake as well as response to nitrogen starvation. In this study we generated two muta...
ORGANISM(S): Schizosaccharomyces pombe 
2009-09-28 | E-GEOD-14626 | biostudies-arrayexpress
ProteomicsRheb and TRF1 PhastID mass spectrometric data
Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1 (mTORC1) to coordinate signaling cascades in response to nutrients and growth factors. Despite extensive studies, the guanine nucleotide exchange factor (GEF) that directly activates Rhe...
ORGANISM(S): Homo Sapiens 
PXD037078 |
ProteomicsTSC-Insensitive Rheb Mutations Induce Oncogenic Transformation Through a Combination of Hyperactive mTORC1 Signalling and Metabolic Reprogramming
The mechanistic target of rapamycin complex 1 (mTORC1) is an important regulator of cellular metabolism that is commonly hyperactivated in cancer. Recent cancer genome screens have identified multiple mutations in Ras-homolog enriched in brain (Rheb), the primary activator of mTORC1, that might act ...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-22 | PXD017006 | Pride
Proteomes Rheb Lc-msms Mtor 
GenomicsEffect of Rheb depletion of Rheb and Ribo-HA knock-in on gene expression of neurons
Effect of Rheb depletion of Rheb and Ribo-HA knock-in on gene expression of neurons
PRJNA960656 | ENA
Genomicsgenes differentially expressed in brown adipose tissue between the control mice (rheb FL/FL) and rheb BAD KO mice (Ucp1-cre rheb FL/FL)
genes differentially expressed in brown adipose tissue between the control mice (rheb FL/FL) and rheb BAD KO mice (Ucp1-cre rheb FL/FL)
PRJNA772588 | ENA
GenomicsMicroarray on T-Rheb -/- CD4+ and CD8+ cells
Microarray on T-Rheb -/- CD4+ and CD8+ cells
PRJNA658258 | ENA
TranscriptomicsTranscription profiling of Caenorhabditis elegans under dietary restriction
Dietary restriction (DR) is the most effective and reproducible intervention to extend lifespan in divergent species1. In mammals, two regimens of DR, intermittent fasting (IF) and caloric restriction (CR), have proven to extend lifespan and reduce the incidence of age-related disorders2. An impor...
ORGANISM(S): Caenorhabditis elegans 
2009-01-13 | E-GEOD-9682 | biostudies-arrayexpress
TranscriptomicsEffect of Rheb depletion of Rheb and Ribo-HA knock-in on gene expression of neurons
To examine the effect of neuronal Rheb on brain myelination, we generated a conditional neuronal Rheb knockout mouse line.
ORGANISM(S): Mus musculus 
2023-05-31 | GSE230354 | GEO
TranscriptomicsMicroarray on T-Rheb -/- CD4+ and CD8+ cells
A microarray was performed on T-Rheb -/- (CD4 cre positive Rheb fl/fl) and Wt C57B6J CD4+ and CD8+ cells. T-Rheb -/- mice had reduced fasting blood glucose and we were interested to see if there was a difference in the T cells that could mediate our phenotype.
ORGANISM(S): Mus musculus 
2021-01-01 | GSE156529 | GEO
Transcriptomicsgenes differentially expressed in brown adipose tissue between the control mice (rheb FL/FL) and rheb BAD KO mice (Ucp1-cre; rheb FL/FL)
RNA sequencing was performed to analyze expression profile in brown adipose tissue with or without rheb knockout.
ORGANISM(S): Mus musculus 
2021-10-21 | GSE186093 | GEO
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