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ProteomicsCirculating Tenascin-C/-miR-155-5p identified as promising prognostic candidates of intervertebral disc herniation
Intervertebral disc (IVD) herniation is a complex and multifactorial condition with challenging diagnosis and limited therapeutic options, highlighting the need for reliable biomarkers to improve clinical decision-making. The aim of this study was to identify circulating prognostic biomarkers of IVD...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-02 | PXD071649 | Pride
Disc herniation Proteomics Mirna Intervertebral disc Circulating biomarkers 
ProteomicsA Minimally-invasive Extracellular Vesicle-based Approach for Monitoring Measurable Residual Disease in Acute Myeloid Leukemia
Measurable residual disease (MRD) in acute myeloid leukemia (AML) is monitored through detection of leukemia associated phenotypic protein markers (LAPMs) in bone marrow aspirates, hindering disease real-time monitoring. We explored peripheral blood (PB) extracellular vesicles (EVs)-based methods fo...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD071884 | Pride
Acute myeloid leukemia  measurable residual disease  liquid biopsies  extracellular vesicles 
ProteomicsLong non-coding RNA H19 regulates matrisome signature and impacts cell behavior on MSC-engineered extracellular matrices
The vast and promising class of long non-coding RNAs (lncRNAs) has been under investigation for distinct therapeutic applications. Nevertheless, their role as molecular drivers of bone regeneration remains poorly studied. The lncRNA H19 mediates osteogenic differentiation of Mesenchymal Stem/Stromal...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD039001 | Pride
Non-coding rnas  fragility fractures  bone extracellular matrix  gene therapy  decellularization 
ProteomicsCardiac tissue remodeling as a new marker to predict cardiac dysfunction induced by radiotherapy.
The contribution of radiotherapy, per se, in late cardiotoxicity remains controversial. An experimental model was developed, in which rat hearts were exposed to a range of ionizing radiation doses, to clarify its impact on the development of early cardiac dysfunction. Rat’s hearts were exposed to da...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-09-08 | PXD033194 | Pride
Gls Cardiac tissue Cardiac muscle Cardiooncology Cardiac dysfunction Radiotherapy 
ProteomicsSyndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival
Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a plasma membrane proteoglycan, is highly expressed in intestinal subtype gastric tumours and that this signature associates with patients’ poor survival. Furth...
ORGANISM(S): Homo sapiens (Human) 
2023-05-05 | PXD035679 | Pride
Extracellular vesicles Extracellular communication Gastric cancer Syndecan-4 Heparan sulfate proteoglycans Cancer cell invasion 
UnknownGlobal burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.
Not available
S-EPMC7567026 | biostudies-literature
UnknownFive insights from the Global Burden of Disease Study 2019.
Not available
S-EPMC7116361 | biostudies-literature
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
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