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ProteomicsCysteine oxidation and disulfide formation in the ribosomal exit tunnel
Understanding the conformational sampling of translation-arrested ribosome nascent chain complexes is key to understand co-translational folding. Up to now, coupling of cysteine oxidation, disulfide bond formation and structure formation in nascent chains has remained elusive. Here, we investigate t...
ORGANISM(S): Bos taurus (Bovine) Escherichia coli 
2020-11-09 | PXD021574 | Pride
Glutathione Ribosomal exit tunnel Cysterine oxidation Disulfide formation 
GenomicsNAC promotes co-translational protein folding at the ribosomal tunnel exit
NAC promotes co-translational protein folding at the ribosomal tunnel exit
PRJNA1230285 | ENA
OtherNAC promotes co-translational protein folding at the ribosomal tunnel exit
The nascent polypeptide-associated complex (NAC) is crucial for protein biogenesis, coordinating enzymatic modifications and membrane targeting of nascent chains at the ribosomal tunnel exit. However, its role in co-translational folding remains unclear. Here, we report the genome-wide profiling of ...
ORGANISM(S): Homo sapiens 
2026-03-23 | GSE290865 | GEO
UnknownThe ribosome modulates folding inside the ribosomal exit tunnel.
Not available
S-EPMC8100117 | biostudies-literature
UnknownCysteine oxidation and disulfide formation in the ribosomal exit tunnel.
Not available
S-EPMC7642426 | biostudies-literature
ProteomicsProtein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit
Proteostasis must be finely tuned in the nervous system, as it represents an essential feature of neurodevelopment, and dominant pathology in neurodegenerative disease. At the gateway of proteostasis is the ribosome; however, the architecture of ribosomal complexes in the developing mammalian brain ...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-04 | PXD014841 | Pride
Development Neocortex Ribosome Ebp1 Proteostasis 
UnknownStructural insights into assembly of the ribosomal nascent polypeptide exit tunnel.
Not available
S-EPMC7547690 | biostudies-literature
UnknownThe ribosomal exit tunnel as a target for optimizing protein expression in Escherichia coli.
Not available
S-EPMC3382190 | biostudies-literature
UnknownHydrophobic and electrostatic interactions modulate protein escape at the ribosomal exit tunnel.
Not available
S-EPMC8595739 | biostudies-literature
GenomicsNascent polypeptide within the exit tunnel stabilizes the ribosome to counteract risky translation
Nascent polypeptide within the exit tunnel stabilizes the ribosome to counteract risky translation
PRJNA764085 | ENA
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