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ProteomicsHsp90-downregulation influences the heat-shock response, innate immune response and onset of oocyte development in nematodes.
Hsp90 is a molecular chaperone involved in the regulation and maturation of kinases and transcription factors. In C. elegans Hsp90 participates in the development of fertility, maintenance of muscle structure and the regulation of stress response and dauer state. To understand the consequences of Hs...
ORGANISM(S): Caenorhabditis elegans 
2018-10-17 | PXD006185 | Pride
Hsp90 Immune system Lc/ms Nematodes 
ProteomicsInvestigation upon the state of p53 as well as interaction partners, in so much as can be learned from using the multi-component v5-dTag system.
Chromatin modifications provide additional context-dependence for DNA sequence-based gene regulation. Binding sites of the transcription factor (TF) and important tumour suppressor p53 are unusually diverse with regards to their chromatin accessibility and histone modifications, suggesting different...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-05 | PXD033674 | Pride
Trim24 Gene regulation Chromatin P53 
ProteomicsReadout of histone methylation by Trim24 locally restricts chromatin opening by p53
The genomic binding sites of the transcription factor (TF) and tumour suppressor p53 are unusually diverse in regards to their chromatin features, including histone modifications, opening the possibility that chromatin provides context-dependence for p53 regulation. Here, we show that the ability of...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-05 | PXD039553 | Pride
Trim24 p53 mouse 
UnknownThe prognostic value of sST2 and galectin-3 considering different aetiologies in non-ischaemic heart failure.
Not available
S-EPMC5845404 | biostudies-literature
UnknownTaxonomic composition, community structure and molecular novelty of microeukaryotes in a temperate oligomesotrophic lake as revealed by metabarcoding.
Not available
S-EPMC9947120 | biostudies-literature
UnknownOther malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY.
Not available
S-EPMC10685149 | biostudies-literature
TranscriptomicsImpact of RNA isolation methods for RNA-seq on gene expression. Here RNA was isolated from HEK293T cells using either Columns, magnetic beads with/without proteinase K or magnetic beads without proteinase K but heating. RNA was processed using prime-seq.
Here silica column and bead based RNA isolation was performed. The two methods were compared using prime-seq to determine the effect of the RNA isolation method on gene expression quantification. This was tested for three different types of input samples, PBMCs, HEK293T cells and striatal mouse tis...
ORGANISM(S): Homo sapiens 
2021-08-01 | E-MTAB-10142 | biostudies-arrayexpress
ProteomicsThe exercise-regulated skeletal muscle phosphoproteome
Four healthy male volunteers (age: 24 - 27; BMI: 24.2 - 25.9 kg/m2) underwent a single bout of high-intensity bicycle exercise reaching a VO2 max approximately 95% with blood samples and muscle biopsies taken immediately pre- and post-exercise. Subjects reached 95% VO2 max in approximately 9 to 12 m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080777 | MassIVE
UnknownRanibizumab in retinopathy of prematurity - one-year follow-up of ophthalmic outcomes and two-year follow-up of neurodevelopmental outcomes from the CARE-ROP study.
Not available
S-EPMC9460412 | biostudies-literature
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
BAT transcriptome from control and brown adipocyte-specific Rev-erbα/β double knockout mice housed at thermoneutrality or cold-challenged for 6 hours. Brown adipose tissue (BAT) samples were collected from control and brown adipocyte-specific Rev-erbα/β double knockout mice (Ucp1-Cre; Nr1d1/2 fl/fl)...
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17580 | biostudies-arrayexpress
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