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TranscriptomicsValvular heart disease and atrial fibrillation regulate microRNA expression profiles in left and right atria differently
Background: Chronic atrial fibrillation (AF) is a complication associated with the dilated atria of patients with valvular heart disease and contributes to worsened pathology. Methods and Results: Using microarray technology, we examined microRNA (miR) expression profiles in right and left atrial ap...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-28954 | biostudies-arrayexpress
ProteomicsProteomics study of right atrium in patients with atrial fibrillation after coronary artery bypass grafting
We performed 4D-labelfree quantitative proteomics analysis of right atrial appendage tissues from 5 patients with atrial fibrillation (AF) and 5 patients with sinus rhythm (SR) after CABG. A total of 2179,559 spectrums and 48,047 peptides were detected by mass spectrometry. Further, we identified 50...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD059685 | Pride
Proteomics Right atrial appendage Atrial fibrillation 
TranscriptomicsAtrial fibrillation is associated with altered left-to-right atria gene expression ratio: implications for arrhythmogenesis and thrombogenesis
Background: Atrial fibrillation (AF) causes atrial remodeling, and the left atrium (LA) is the favored substrate for maintaining AF. However, it remains unclear if AF remodels both atria differently and contributes to LA arrhythmogenesis and thrombogenesis. Results: AF was associated with differenti...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-79768 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of normal and abnormal chick myocardial development
The goal of this study was to determine developmental differences in gene expression between left and right ventricle, and to assess the differential effect of altered hemodynamic loading on left and right ventricle. Chick ventricles from different developmental stages were isolated for assessment o...
ORGANISM(S): Gallus gallus 
2012-12-28 | E-GEOD-37070 | biostudies-arrayexpress
ProteomicsAtlas of lysine propionylation in the human right atrium reveals ALDH6A1-NADH pathway involved in the new-onset atrial fibrillation in aging after coronary artery bypass grafting
Lysine propionylation modification (Kpr) plays an important role in the pathogenesis of several cardiovascular diseases, but the role of Kpr in postoperative atrial fibrillation (POAF) is unclear. Here, we established an atlas of proteomics and propionylation proteomics in the atrial appendage tissu...
ORGANISM(S): Homo sapiens (Human) 
2025-08-11 | PXD059607 | Pride
Propionylation Aldh6a1 Atrial fibrillation Coronary artery bypass grafting 
GenomicsIschemic heart disease selectively modifies the right atrial appendage transcriptome
Ischemic heart disease selectively modifies the right atrial appendage transcriptome
PRJNA726237 | ENA
ProteomicsTranscriptome and Proteome Mapping in the Sheep Atria Reveal Molecular Features of Atrial Fibrillation Progression
Atrial fibrillation (AF) is often a progressive cardiac arrhythmia that increases the risk of hospitalization and adverse cardiovascular events. There is a clear demand for more inclusive and large-scale approaches to understand the molecular drivers responsible for AF, as well as the fundamental me...
ORGANISM(S): Ovis aries 
2021-01-08 | PXD015637 | Pride
Data integration Cardiovascular disease Proteomics Transcriptomics Atrial fibrillation 
TranscriptomicsMolecular Remodeling of Ion Channels in Human Atrial and Ventricular Myocytes Associated with Ischemic Cardiomyopathy
Ischemic cardiomyopathy (ICM) leads to congestive heart failure and can cause sudden cardiac death due to arrhythmia. Existing molecular knowledge base of ICM is rudimentary because of lack of specific attribution to cell type and function. This study was designed to investigate cell-specific molecu...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-17294 | biostudies-arrayexpress
TranscriptomicsComparison of microRNA expression after AF-Ablation with Cryo balloon vs. Pulsed field ablation
Human citrate Plasma was collected from the left atrial appendage directly after catheter ablation for atrial fibrillation with either teh Boston Scientific Cryo-Balloon System or the Boston Scientific Pulsed Field Ablation System. A total of 154 microRNAs (miRs) were consistently detected across a...
ORGANISM(S): Homo sapiens 
2025-12-31 | E-MTAB-14837 | biostudies-arrayexpress
TranscriptomicsExposure to 60 minutes of hyperoxia upregulates myocardial humanins in patients with coronary artery disease
Background. In experimental setting the concept of myocardial preconditioning-by hyperoxia has been introduced and different intracellular protective mechanisms and their effects have been described. To study whether similar protective phenotype can be induced by hyperoxia also in humans, gene expre...
ORGANISM(S): Homo sapiens 
2015-02-25 | E-GEOD-66249 | biostudies-arrayexpress
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