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TranscriptomicsDownregulation of specific miRNAs in hyperdiploid multiple myeloma mimics the oncogenic effect of IgH translocations occurring in the non-hyperdiploid subtype
Currently, multiple myeloma (MM) patients are broadly grouped into a non-hyperdiploid Group (nh-MM), highly enriched for IgH translocations, or into a hyperdiploid Group (h-MM), which is typically characterized by trisomies of some odd-numbered chromosomes. We compared the miRNA expression profiles...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-40308 | biostudies-arrayexpress
UnknownA dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.
Not available
S-EPMC9380745 | biostudies-literature
UnknownRecurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree.
Not available
S-EPMC5567149 | biostudies-literature
UnknownA frameshift variant in specificity protein 1 triggers superactivation of Sp1-mediated transcription in familial bone marrow failure.
Not available
S-EPMC7382244 | biostudies-literature
UnknownGermline heterozygous DDX41 variants in a subset of familial myelodysplasia and acute myeloid leukemia.
Not available
S-EPMC5008455 | biostudies-literature
UnknownBPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis.
Not available
S-EPMC4728380 | biostudies-literature
ProteomicsCKS1-dependent proteostatic regulation has dual roles in combating acute myeloid leukemia whilst protecting normal hematopoiesis
Acute myeloid leukemia (AML) is an aggressive hematological disorder comprised of a hierarchy of quiescent leukemic stem cells and fast proliferating blasts with limited self-renewal ability. Significant plasticity in the AML epigenome and metabolome results in a high rate of drug resistance and rel...
ORGANISM(S): Homo sapiens (Human) 
2022-07-20 | PXD022754 | Pride
Proteostasis Chemotherapy Cks1 Hematopoiesis Aml Protein degradation 
UnknownAbrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22).
Not available
S-EPMC3347656 | biostudies-literature
ProteomicsPhosphoproteomics of primary acute myeloid leukemia cells with rearranged KMT2A
Acute myeloid leukemia (AML) is a disease with poor outcome but patients harbouring certain chromosomal rearrangements or complex karyotypes have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. To understand the molecular landsc...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036669 | Pride
Aml Phosphoproteomics Genomics Kmt2a Impdh Drug screen Nucleolus Proteomics 
ProteomicsPhosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes
Acute myeloid leukemia (AML) is a disease with poor outcome but patients harbouring certain chromosomal rearrangements or complex karyotypes have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. To understand the molecular landsc...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032980 | Pride
Aml Phosphoproteomics Genomics Kmt2a Impdh Drug screen Nucleolus Proteomics 
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