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MetabolomicsTreatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomics
Introduction: Obestatin is a controversial gastrointestinal peptide purported to have metabolic actions. Objectives: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys10, Cys13) changed plasma metabolite levels firstly in lean and subsequently in diet-induced obes...
2017-07-25 | MTBLS334 | MetaboLights
ProteomicsExtracellular vesicles impose quiescence and confer DNA-damage on residual HSC in the AML niche
To understand the mechanism by which AML-EVs may enforce quiescence, we performed tandem mass tag (TMT) proteomic profiling of in vitro cultured c-Kit+ hematopoietic stem and progenitor cells (HSPC) (to obtain the minimum required amount of protein lysates) treated with extracellular vesicles (EVs) ...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-24 | PXD013688 | Pride
Aml-derived extracellular vesicles Isobaric labeling Proteomics Bone marrow Acute myeloid leukemia (aml) Mouse Tandem mass tags 
UnknownTime to Gender-Affirming Hormone Therapy Among US Military-Affiliated Adolescents and Young Adults.
Not available
S-EPMC11334009 | biostudies-literature
UnknownEffects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates.
Not available
S-EPMC8455324 | biostudies-literature
ProteomicsEvaluation of NCI-7 Cell Line Panel
Reference materials are vital to benchmarking the reproducibility of clinical tests and essential for monitoring laboratory performance for clinical proteomics. The reference material utilized for mass spectrometric analysis of the human proteome would ideally contain enough proteins to be suitably ...
ORGANISM(S): Homo sapiens (Human) 
2018-05-14 | PXD008952 | Pride
Nci-60 Proteomics reference standard Nci-7 Cptac 
TranscriptomicsIndices of Tolerance (IOT): Cross-platform biomarkers that identify kidney transplant tolerance
Being able to identify patients in whom immunological tolerance has been established or is developing would allow an individually tailored approach to post-transplant management of kidney allograft recipients. Ex vivo immunological monitoring was performed on samples from five groups of European ren...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-14655 | biostudies-arrayexpress
UnknownStrategies to build trustworthiness and increase diversity in colorectal cancer biospecimen research: a multi-phase, multi-site qualitative study.
Not available
S-EPMC12764713 | biostudies-literature
UnknownA Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay.
Not available
S-EPMC5294886 | biostudies-literature
UnknownRecurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders.
Not available
S-EPMC4098665 | biostudies-literature
ProteomicsTumour mtDNA mutations drive aerobic glycolysis to enhance checkpoint blockade (part 2)
Mitochondrial DNA (mtDNA) encodes essential machinery for respiration and metabolic homeostasis but is paradoxically among the most common targets of somatic mutations in the cancer genome, with truncating mutations in complex I genes being over-represented1 . While mtDNA mutations have been associ...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-08 | PXD044987 | Pride
Melanoma Cancer Complex i Mitochondrial dna 
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