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TranscriptomicsInnate immune pathways in afferent lymph following vaccination with poly(I:C) -containing liposomes
Many modern vaccines use defined adjuvants to stimulate the innate immune system and shape the adaptive immune response. The exact nature of these innate signals and whether immune differentiation can originate within the periphery is not known. In the present study we used an ovine lymphatic cannul...
ORGANISM(S): Ovis aries 
2013-08-01 | E-GEOD-38533 | biostudies-arrayexpress
TranscriptomicsCXCR3+ Treg cells suppress Th1-immune responses through expression of the co-inhibitory receptors CD85k and Lag-3
CD4+Foxp3+ Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control Th1 responses. T-bet-dependent expression of CXC...
ORGANISM(S): Mus musculus 
2018-06-30 | E-MTAB-6156 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver, lung, spleen and kidney from young (13 week) and aged (130 week) wild type mice
We compared the complete mouse liver, spleen, lung and kidney transcriptome of adult 13- and 130-wk old wt C57Bl/6J mice (n=3) to develop gene sets for young adult and aged wt mice, respectively
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1504 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from wild type or Ercc1 mutant mice
The XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA damage and interstrand crosslinks. Here we have engineered a severe mutation in Ercc1 gene (in which the last 7 amino acids are missing; named as "Ercc1-delta") leading to extreme sensitivity to DNA crosslinks and progeria.To ...
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1503 | biostudies-arrayexpress
TranscriptomicsGlobal Analysis of the Immediate Transcriptional Effects of Estrogen Signaling Reveals a Rapid, Extensive, and Transient Response
We report the immediate effects of estrogen signaling on the transcriptome of breast cancer cells using Global Run-On and sequencing (GRO-seq). We found that estrogen signaling directly regulates a strikingly large fraction of the transcriptome in a rapid, robust, and unexpectedly transient manner. ...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-27463 | biostudies-arrayexpress
TranscriptomicsDual RNA-seq of parasite and host reveals gene expression dynamics during filarial worm-mosquito interactions
Parasite biology, by its very nature, cannot be understood without integrating it with that of the host, nor can the host response be adequately explained without considering the activity of the parasite. However, due to experimental limitations, molecular studies of parasite-host systems have been ...
ORGANISM(S): Aedes aegypti 
2014-04-15 | E-GEOD-53664 | biostudies-arrayexpress
TranscriptomicsFive Omic Technologies Are Concordant in Differentiating the Biochemical Characteristics of the Berries of Five Grapevine (Vitis vinifera L.) Cultivars
Background: Grape cultivars and wines are distinguishable by their color, flavor and aroma profiles. Omic analyses (transcripts, proteins and metabolites) are powerful tools for assessing biochemical differences in biological systems. Results: Berry skins of red- (Cabernet Sauvignon, Merlot, Pinot ...
ORGANISM(S): Vitis vinifera 
2015-11-12 | E-GEOD-72421 | biostudies-arrayexpress
UnknownSoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development.
Not available
S-EPMC5536923 | biostudies-literature
UnknownAncestry of the Timorese: age-related macular degeneration associated genotype and allele sharing among human populations from throughout the world.
Not available
S-EPMC4496576 | biostudies-literature
TranscriptomicsTranscription profiling of known iron genes in liver, spleen and duodenum of C57BL/6J and SWR mouse strains which have low and high basal iron levels respectively
Comparison of expression of known 'iron' genes in liver, spleen and duodenum of C57BL/6J and SWR mouse strains which have low and high basal iron levels respectively.
ORGANISM(S): Mus musculus 
2006-07-11 | E-MEXP-486 | biostudies-arrayexpress
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