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TranscriptomicsTranscriptome of the maturing erythroblast
Understanding the pattern of gene expression and identifying the specific genes expressed during erythropoiesis is crucial for a synthesis of erythroid developmental biology. Here we have isolated four distinct populations of erythroblasts at successive erythropoietin-dependent stages of erythropoie...
ORGANISM(S): Homo sapiens 
2011-03-02 | E-GEOD-22552 | biostudies-arrayexpress
TranscriptomicsBET Protein Inhibition shows Efficacy Against JAK2V617F-Driven Neoplasms
Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of MLL-fusion protein driven leukemias. Here, we report that I-BET151, a highly specific BET family bromodomain inhibitor...
ORGANISM(S): Homo sapiens 
2013-08-20 | E-MTAB-1817 | biostudies-arrayexpress
TranscriptomicsLoss of full-length dystrophin expression causes major cell-autonomous abnormalities in proliferating myoblasts
Duchenne muscular dystrophy (DMD) is a severely debilitating and incurable neuromuscular disease. Its conspicuous feature is the absence of dystrophin in myofibers and therefore most therapeutic approaches focus on some form of its re-expression there. However, increasing body of evidence points at ...
ORGANISM(S): Mus musculus 
2022-09-14 | E-MTAB-10322 | biostudies-arrayexpress
GenomicsDriver mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in Acute Myeloid Leukemia
Recent evidence suggests that inhibition of BET epigenetic readers may have clinical utility in hematological malignancies. We demonstrate the efficacy of the BET inhibitor I-BET151 across a variety of AML subtypes, and demonstrate that a common core transcriptional program, which is HOX gene-indepe...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-MTAB-1443 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of 7SK knockdown in mouse embryonic stem cells
Transcriptome profiling of mouse embryonic stem cells following antisense knockdown of the non-coding RNA 7SK.
ORGANISM(S): Mus musculus 
2013-09-09 | E-MTAB-1585 | biostudies-arrayexpress
UnknownIllustrating Cancer Risk: Patient Risk Communication Preferences and Interest regarding a Novel BRCA1/2 Genetic Risk Modifier Test.
Not available
S-EPMC7272266 | biostudies-literature
TranscriptomicsTranscription profiling by array of mouse epidermis and pancreas following MycERTAM activation at 4 time points
The transcription factor Myc is a critical regulator of diverse cellular processes, including both replication and apoptosis. However, differences in Myc-regulated gene expression responsible for such opposing outcomes in vivo remain obscure. To address this we have examined time-dependent changes i...
ORGANISM(S): Mus musculus 
2010-12-01 | E-MEXP-2952 | biostudies-arrayexpress
ProteomicsSexual Dimorphism of Plasma Proteomes in Human Calcific Aortic Valve Stenosis
Females are underrepresented in studies of calcific aortic valve stenosis (CAVS), leading to delay in timely intervention and increased mortality. Histopathology demonstrates female CAVS presents with decreased valvular calcification but increased fibrosis and severity of symptoms. CAVS plasma sampl...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD064030 | Pride
Human Lc-msms Calcification Aortic valve Fibrosis Sex disparities 
UnknownProspective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms.
Not available
S-EPMC6186514 | biostudies-literature
UnknownImpact of glucocorticoids on patients' quality of life: a qualitative study assessing face validity and feasibility of the Steroid PRO in patients with inflammatory gastroenterology, respiratory and dermatology conditions.
Not available
S-EPMC11800201 | biostudies-literature
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