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ProteomicsExtra and quantitatve intracellular proteomics for Streptomyces sp. SirexAA-E
In this study, we performed an extracellular proteomics and pair-wise TMT-labeling quantitative intracellular proteomics of SirexAA-E grown on glucose, xylose, xylobiose, or xylan-containing medium to gain a knowledge of extracellular and intracellular xylan responses of this bacterium. Moreover, th...
ORGANISM(S): Streptomyces sp. SirexAA-E 
2025-11-11 | PXD067972 | Pride
Tmt Streptomyces sp. sirexaa-e 
ProteomicsPulldown proteomics of XybR in SirexAA-E
Streptomyces sp. SirexAA-E chnages secretion of enzymes that can degrade xylan. These enzymes transcription is regulated by a transcriptional regulator. To determine the dominant regulator, we performed pulldown proteomics, using some promoter regions (P0265, P0357, P5230) which are related to xylan...
ORGANISM(S): Streptomyces sp. SirexAA-E 
2025-11-11 | PXD061680 | Pride
Pulldown proteomics Xylan Hemicellulose Transcriptonal regulator 
TranscriptomicsTranscription profiling of human dendritic cells matured by cadherin reveals disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation
The maturation of dendritic cells (DCs) after exposure to microbial products or inflammatory mediators plays a critical role in initiating the immune response. We found that maturation can also occur under steady state conditions, triggered by alterations in E-cadherin-mediated DC-DC adhesion. Sele...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9241 | biostudies-arrayexpress
ProteomicsMannose and mannobiose specific responses of insect associated cellulolytic Streptomyces.
The cellulolytic insect symbiont bacterium, Streptomyces sp. SirexAA-E (SirexAA-E), is known to secrete a suite of Carbohydrate Active enZymes (CAZymes) for plant cell wall degradation in response to the available carbon sources. In this study, we sought to examine a poorly understood response of th...
ORGANISM(S): Streptomyces sp. SirexAA-E 
2021-05-06 | PXD022202 | Pride
Proteomics analysis Streptomyces sp. sirexaa-e Cellulose utilization Glycoside hydrolases Transcriptional regulation 
TranscriptomicsIdentification of novel tissue-specific transcription arising from E-cadherin/CDH1 intron2: a novel protein isoform increases gastric cancer cell invasion and angiogenesis.
E-cadherin, a protein encoded by the CDH1 gene is the dominant epithelial cell adhesion molecule playing a crucial role in epithelial tissue polarity and structural integrity. The progression of 90% or more carcinomas is believed to be mediated by disruption of normal E-cadherin expression, subcellu...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-32540 | biostudies-arrayexpress
TranscriptomicsCarbon nutrition of pathogenic and commensal E. coli
Transcriptome profiling of E. coli MG1655, E. coli EDL933, E. coli ECOR26, and E. coli Nissle 1917 grown on mouse cecal mucus as carbon source The carbon sources that support growth of pathogenic E. coli O157:H7 in the mammalian intestine have not previously been investigated. In vivo, pathogenic E...
ORGANISM(S): Escherichia coli 
2008-04-25 | E-GEOD-11254 | biostudies-arrayexpress
ProteomicsHuman B-ALL HLA-E Immunopeptidomics (3D12)
HLA-E immunoenrichment and mass spectrometric analysis of primary B-ALL cells (STEMCELL Technologies, 200-0449).
ORGANISM(S): Homo sapiens (Human) 
2026-10-05 | PXD081386 | Pride
B-all Immunopeptidomics Hla-e 
ProteomicsTargeting ERAP enhances anti-tumor immunity by disrupting the NKG2A/HLA-E inhibitory checkpoint
New targets that enhance anti-tumor immunity must be identified to improve the efficacy of cancer immunotherapy. Here we show that loss of endoplasmic reticulum aminopeptidase (ERAP) family proteins improves anti-tumor immunity and synergizes with immune checkpoint blockade. Mechanistically, we show...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD052031 | Pride
Human Hla-e Orbitrap Immunotherapy 
TranscriptomicsTranscription profiling by array of mouse wild type and E-cadherin knockout embryonic stem cells grown with or without cytokine leukemia inhibitory factor
We previously observed that E-cadherin knockout embryonic stem cells do not differentiate in the absence of the cytokine leukemia inhibitory factor (LIF) (Soncin et al., 2009, Stem Cells 27 p2069-2080). This experiment was designed to compare the transcription profile of E-cadherin KO ES cells cultu...
ORGANISM(S): Mus musculus 
2011-06-19 | E-MEXP-2836 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E. coli K12 luxS-dependent gene regulation
The bacterial quorum-sensing autoinducer 2 (AI-2) has received intense interest because the gene for its synthase, luxS, is common among a large number of bacterial species. We have identified luxS-controlled genes in Escherichia coli under two different growth conditions using DNA microarrays. Twen...
ORGANISM(S): Escherichia coli 
2008-06-16 | E-GEOD-9582 | biostudies-arrayexpress
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